TY - JOUR
T1 - Suppression of enriched environment-induced neurogenesis in a rodent model of neuropathic pain
AU - Terada, Mioko
AU - Kuzumaki, Naoko
AU - Hareyama, Nana
AU - Imai, Satoshi
AU - Niikura, Keiich
AU - Narita, Michiko
AU - Yamazaki, Mitsuaki
AU - Suzuki, Tsutomu
AU - Narita, Minoru
PY - 2008/8/8
Y1 - 2008/8/8
N2 - Exposure to an enriched environment (EE) enhances neurogenesis and regulates emotionality. Previous reports have revealed that the rate of neurogenesis can be influenced by various environmental, endocrine, and pharmacologic stimuli. Chronic pain is a debilitating disease state characterized by complex alterations in both peripheral and central nociceptive pathways. In the present study, we evaluated the effect of chronic pain on environmental enrichment-induced hippocampal neurogenesis. Nerve-ligated mice were housed either in a standard environment or in the EE for 4 weeks. EE increased the immunoreactivity for doublecortin (DCX), a marker for immature neuron-positive cells, in the dentate gyrus (DG). Furthermore, the number of NeuroD (a neurogenic basic helix-loop-helix factor)-positive cells, in the DG was clearly increased by EE. Under these conditions, chronic pain suppressed enriched environment-mediated induction of both DCX- and NeuroD-labeled cells. These results suggest that chronic pain has stress-like damaging modulatory effects on hippocampal neurogenesis.
AB - Exposure to an enriched environment (EE) enhances neurogenesis and regulates emotionality. Previous reports have revealed that the rate of neurogenesis can be influenced by various environmental, endocrine, and pharmacologic stimuli. Chronic pain is a debilitating disease state characterized by complex alterations in both peripheral and central nociceptive pathways. In the present study, we evaluated the effect of chronic pain on environmental enrichment-induced hippocampal neurogenesis. Nerve-ligated mice were housed either in a standard environment or in the EE for 4 weeks. EE increased the immunoreactivity for doublecortin (DCX), a marker for immature neuron-positive cells, in the dentate gyrus (DG). Furthermore, the number of NeuroD (a neurogenic basic helix-loop-helix factor)-positive cells, in the DG was clearly increased by EE. Under these conditions, chronic pain suppressed enriched environment-mediated induction of both DCX- and NeuroD-labeled cells. These results suggest that chronic pain has stress-like damaging modulatory effects on hippocampal neurogenesis.
KW - Environmental enrichment
KW - Hippocampus
KW - Neurogenesis
KW - Pain
UR - http://www.scopus.com/inward/record.url?scp=45849107598&partnerID=8YFLogxK
U2 - 10.1016/j.neulet.2008.05.078
DO - 10.1016/j.neulet.2008.05.078
M3 - 学術論文
C2 - 18565655
AN - SCOPUS:45849107598
SN - 0304-3940
VL - 440
SP - 314
EP - 318
JO - Neuroscience Letters
JF - Neuroscience Letters
IS - 3
ER -