Suppression of enriched environment-induced neurogenesis in a rodent model of neuropathic pain

Mioko Terada, Naoko Kuzumaki, Nana Hareyama, Satoshi Imai, Keiich Niikura, Michiko Narita, Mitsuaki Yamazaki*, Tsutomu Suzuki, Minoru Narita

*この論文の責任著者

研究成果: ジャーナルへの寄稿学術論文査読

44 被引用数 (Scopus)

抄録

Exposure to an enriched environment (EE) enhances neurogenesis and regulates emotionality. Previous reports have revealed that the rate of neurogenesis can be influenced by various environmental, endocrine, and pharmacologic stimuli. Chronic pain is a debilitating disease state characterized by complex alterations in both peripheral and central nociceptive pathways. In the present study, we evaluated the effect of chronic pain on environmental enrichment-induced hippocampal neurogenesis. Nerve-ligated mice were housed either in a standard environment or in the EE for 4 weeks. EE increased the immunoreactivity for doublecortin (DCX), a marker for immature neuron-positive cells, in the dentate gyrus (DG). Furthermore, the number of NeuroD (a neurogenic basic helix-loop-helix factor)-positive cells, in the DG was clearly increased by EE. Under these conditions, chronic pain suppressed enriched environment-mediated induction of both DCX- and NeuroD-labeled cells. These results suggest that chronic pain has stress-like damaging modulatory effects on hippocampal neurogenesis.

本文言語英語
ページ(範囲)314-318
ページ数5
ジャーナルNeuroscience Letters
440
3
DOI
出版ステータス出版済み - 2008/08/08

ASJC Scopus 主題領域

  • 神経科学一般

フィンガープリント

「Suppression of enriched environment-induced neurogenesis in a rodent model of neuropathic pain」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル