Structures and biological evaluation of phenylpropanoid derivatives from Dendrobium Sonia

Bai xiang Cai; Lei xin Song; Hai jun Hu; Zhu zhen Han; Yue Zhou; Zheng tao Wang; Li Yang

doi:10.1080/14786419.2020.1782404

Structures and biological evaluation of phenylpropanoid derivatives from Dendrobium Sonia

Bai xiang Cai, Lei xin Song, Hai jun Hu, Zhu zhen Han, Yue Zhou, Zheng tao Wang, Li Yang^*

^*この論文の責任著者

がん細胞生物学研究室

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

4 被引用数 (Scopus)

抄録

Two new phenylpropanoid derivatives (1-2), together with eight known compounds (3-10) were isolated from the stems of Dendrobium sonia. The structures of these compounds were elucidated on the basis of spectroscopic analyses, including HRESIMS, 1 D and 2 D NMR experiments. All of the isolated compounds were tested for their Nitric Oxide (NO) Inhibitory Activities. The results of bioactive screening showed that compounds 2, 8, 9 and 10 exerted inhibitory effects on NO production with IC₅₀ values in the range of 26.3 to 31.6 μM. Compound 8 and 9 exhibited stronger anti-inflammatory activities with IC₅₀ values 26.3 and 27.7 μM, comparable to that of the positive control.

本文言語	英語
ページ（範囲）	5120-5124
ページ数	5
ジャーナル	Natural Product Research
巻	35
号	23
DOI	https://doi.org/10.1080/14786419.2020.1782404
出版ステータス	出版済み - 2021

ASJC Scopus 主題領域

分析化学
生化学
植物科学
有機化学

文献へのアクセス

10.1080/14786419.2020.1782404

引用スタイル

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title = "Structures and biological evaluation of phenylpropanoid derivatives from Dendrobium Sonia",

abstract = "Two new phenylpropanoid derivatives (1-2), together with eight known compounds (3-10) were isolated from the stems of Dendrobium sonia. The structures of these compounds were elucidated on the basis of spectroscopic analyses, including HRESIMS, 1 D and 2 D NMR experiments. All of the isolated compounds were tested for their Nitric Oxide (NO) Inhibitory Activities. The results of bioactive screening showed that compounds 2, 8, 9 and 10 exerted inhibitory effects on NO production with IC50 values in the range of 26.3 to 31.6 μM. Compound 8 and 9 exhibited stronger anti-inflammatory activities with IC50 values 26.3 and 27.7 μM, comparable to that of the positive control.",

keywords = "Dendrobium Sonia, Nitric oxide inhibitory activity, phenylpropanoid",

author = "Cai, {Bai xiang} and Song, {Lei xin} and Hu, {Hai jun} and Han, {Zhu zhen} and Yue Zhou and Wang, {Zheng tao} and Li Yang",

note = "Publisher Copyright: {\textcopyright} 2020 Informa UK Limited, trading as Taylor & Francis Group.",

year = "2021",

doi = "10.1080/14786419.2020.1782404",

language = "英語",

volume = "35",

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journal = "Natural Product Research",

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TY - JOUR

T1 - Structures and biological evaluation of phenylpropanoid derivatives from Dendrobium Sonia

AU - Cai, Bai xiang

AU - Song, Lei xin

AU - Hu, Hai jun

AU - Han, Zhu zhen

AU - Zhou, Yue

AU - Wang, Zheng tao

AU - Yang, Li

PY - 2021

Y1 - 2021

N2 - Two new phenylpropanoid derivatives (1-2), together with eight known compounds (3-10) were isolated from the stems of Dendrobium sonia. The structures of these compounds were elucidated on the basis of spectroscopic analyses, including HRESIMS, 1 D and 2 D NMR experiments. All of the isolated compounds were tested for their Nitric Oxide (NO) Inhibitory Activities. The results of bioactive screening showed that compounds 2, 8, 9 and 10 exerted inhibitory effects on NO production with IC50 values in the range of 26.3 to 31.6 μM. Compound 8 and 9 exhibited stronger anti-inflammatory activities with IC50 values 26.3 and 27.7 μM, comparable to that of the positive control.

AB - Two new phenylpropanoid derivatives (1-2), together with eight known compounds (3-10) were isolated from the stems of Dendrobium sonia. The structures of these compounds were elucidated on the basis of spectroscopic analyses, including HRESIMS, 1 D and 2 D NMR experiments. All of the isolated compounds were tested for their Nitric Oxide (NO) Inhibitory Activities. The results of bioactive screening showed that compounds 2, 8, 9 and 10 exerted inhibitory effects on NO production with IC50 values in the range of 26.3 to 31.6 μM. Compound 8 and 9 exhibited stronger anti-inflammatory activities with IC50 values 26.3 and 27.7 μM, comparable to that of the positive control.

KW - Dendrobium Sonia

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DO - 10.1080/14786419.2020.1782404

M3 - 学術論文

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SN - 1478-6419

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Structures and biological evaluation of phenylpropanoid derivatives from Dendrobium Sonia

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