SNARE proteins: Zip codes in vesicle targeting?

Seiichi Koike, Reinhard Jahn*

*この論文の責任著者

研究成果: ジャーナルへの寄稿総説査読

45 被引用数 (Scopus)

抄録

Membrane traffic in eukaryotic cells is mediated by transport vesicles that bud from a precursor compartment and are transported to their destination compartment where they dock and fuse. To reach their intracellular destination, transport vesicles contain targeting signals such as Rab GTPases and polyphosphoinositides that are recognized by tethering factors in the cytoplasm and that connect the vesicles with their respective destination compartment. The final step, membrane fusion, is mediated by SNARE proteins. SNAREs are connected to targeting signals and tethering factors by multiple interactions. However, it is still debated whether SNAREs only function downstream of targeting and tethering or whether they also participate in regulating targeting specificity. Here, we review the evidence and discuss recent data supporting a role of SNARE proteins as targeting signals in vesicle traffic.

本文言語英語
ページ(範囲)273-288
ページ数16
ジャーナルBiochemical Journal
479
3
DOI
出版ステータス出版済み - 2022/02

ASJC Scopus 主題領域

  • 生化学
  • 分子生物学
  • 細胞生物学

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