Sludge reflects intra-amniotic inflammation with or without microorganisms

Noriko Yoneda, Satoshi Yoneda, Hideki Niimi, Masami Ito, Kaori Fukuta, Tomohiro Ueno, Mika Ito, Arihiro Shiozaki, Mika Kigawa, Isao Kitajima, Shigeru Saito*

*この論文の責任著者

研究成果: ジャーナルへの寄稿学術論文査読

23 被引用数 (Scopus)

抄録

Problem: To investigate whether amniotic fluid (AF) “sludge” in patients with preterm labor (PTL) with intact membranes is related to intra-amniotic infection or inflammation. Method of study: 105 PTL patients before 29 weeks’ gestation were enrolled. AF “sludge” was evaluated by transvaginal sonography. Microorganisms were identified in AF by our newly established PCR method using a eukaryote-made thermostable DNA polymerase. Results: AF “sludge” was present in 18.1% (19/105) of patients. The results obtained in the AF “sludge” group vs the no “sludge” group were as follows: (i) a similar positive rate of microorganisms in AF by PCR, 31.6% (6/19) vs 38.4% (33/86); (ii) a higher level of AF interleukin-8, 15.2 (0.2-381.5) ng/mL vs 5.8 (0.1-413.7) ng/mL; P =.005); and (3) a higher frequency of histological chorioamnionitis, 52.6% (10/19) vs 23.3% (20/86); P =.010. Conclusion: The presence of AF “sludge” is related to intra-amniotic inflammation with or without microorganisms.

本文言語英語
論文番号e12807
ジャーナルAmerican Journal of Reproductive Immunology
79
2
DOI
出版ステータス出版済み - 2018/02

ASJC Scopus 主題領域

  • 免疫アレルギー学
  • 免疫学
  • 生殖医学
  • 産婦人科学

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