抄録
Modern lifestyles prolong daily activities into the nighttime, disrupting circadian rhythms, which may cause sleep disturbances. Sleep disturbances have been implicated in the dysregulation of blood glucose levels and reported to increase the risk of type 2 diabetes (T2D) and diabetic complications. Sleep disorders are treated using anti-insomnia drugs that target ionotropic and G protein-coupled receptors (GPCRs), including γ-aminobutyric acid (GABA) agonists, melatonin agonists, and orexin receptor antagonists. A deeper understanding of the effects of these medications on glucose metabolism and their underlying mechanisms of action is crucial for the treatment of diabetic patients with sleep disorders. In this review we focus on the beneficial impact of sleep on glucose metabolism and suggest a possible strategy for therapeutic intervention against sleep-related metabolic disorders.
本文言語 | 英語 |
---|---|
ページ(範囲) | 633-642 |
ページ数 | 10 |
ジャーナル | Trends in Endocrinology and Metabolism |
巻 | 27 |
号 | 9 |
DOI | |
出版ステータス | 出版済み - 2016 |
ASJC Scopus 主題領域
- 内分泌学、糖尿病および代謝内科学
- 内分泌学