Sleep Control, GPCRs, and Glucose Metabolism

Hiroshi Tsuneki, Toshiyasu Sasaoka*, Takeshi Sakurai

*この論文の責任著者

研究成果: ジャーナルへの寄稿総説査読

29 被引用数 (Scopus)

抄録

Modern lifestyles prolong daily activities into the nighttime, disrupting circadian rhythms, which may cause sleep disturbances. Sleep disturbances have been implicated in the dysregulation of blood glucose levels and reported to increase the risk of type 2 diabetes (T2D) and diabetic complications. Sleep disorders are treated using anti-insomnia drugs that target ionotropic and G protein-coupled receptors (GPCRs), including γ-aminobutyric acid (GABA) agonists, melatonin agonists, and orexin receptor antagonists. A deeper understanding of the effects of these medications on glucose metabolism and their underlying mechanisms of action is crucial for the treatment of diabetic patients with sleep disorders. In this review we focus on the beneficial impact of sleep on glucose metabolism and suggest a possible strategy for therapeutic intervention against sleep-related metabolic disorders.

本文言語英語
ページ(範囲)633-642
ページ数10
ジャーナルTrends in Endocrinology and Metabolism
27
9
DOI
出版ステータス出版済み - 2016

ASJC Scopus 主題領域

  • 内分泌学、糖尿病および代謝内科学
  • 内分泌学

フィンガープリント

「Sleep Control, GPCRs, and Glucose Metabolism」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル