Site of ketamine action on the NMDA receptor

Hisashi Mori*

*この論文の責任著者

研究成果: 書籍の章/レポート/会議録査読

1 被引用数 (Scopus)

抄録

Ketamine, an antagonist of N-methyl-d-aspartate receptors (NMDARs), produces rapid and sustained reduction of symptoms in patients with treatment-resistant depression. NMDARs are critical for neural network formation, neuronal plasticity, higher brain functions, and pathophysiology of neurodegenerative and psychiatric disorders. Recent studies have identified functional domains of diverse NMDAR subunits, as well as the site of ketamine action on NMDARs. The site of ketamine action overlaps with the site of physiological voltage-dependent Mg2+ block. Furthermore, different NMDAR GluN2 subunits contribute differentially to the sensitivity of ketamine. High-resolution analyses of the structure of the action site of ketamine on NMDARs and the mechanisms of ketamine action in vivo will contribute to the development of novel and effective antidepressant drugs.

本文言語英語
ホスト出版物のタイトルKetamine
ホスト出版物のサブタイトルFrom Abused Drug to Rapid-Acting Antidepressant
出版社Springer Singapore
ページ47-67
ページ数21
ISBN(電子版)9789811529023
ISBN(印刷版)9789811529016
DOI
出版ステータス出版済み - 2020/01/01

ASJC Scopus 主題領域

  • 薬理学、毒性学および薬学一般
  • 神経科学一般
  • 農業および生物科学一般
  • 医学一般
  • 心理学一般

フィンガープリント

「Site of ketamine action on the NMDA receptor」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル