抄録
Ketamine, an antagonist of N-methyl-d-aspartate receptors (NMDARs), produces rapid and sustained reduction of symptoms in patients with treatment-resistant depression. NMDARs are critical for neural network formation, neuronal plasticity, higher brain functions, and pathophysiology of neurodegenerative and psychiatric disorders. Recent studies have identified functional domains of diverse NMDAR subunits, as well as the site of ketamine action on NMDARs. The site of ketamine action overlaps with the site of physiological voltage-dependent Mg2+ block. Furthermore, different NMDAR GluN2 subunits contribute differentially to the sensitivity of ketamine. High-resolution analyses of the structure of the action site of ketamine on NMDARs and the mechanisms of ketamine action in vivo will contribute to the development of novel and effective antidepressant drugs.
本文言語 | 英語 |
---|---|
ホスト出版物のタイトル | Ketamine |
ホスト出版物のサブタイトル | From Abused Drug to Rapid-Acting Antidepressant |
出版社 | Springer Singapore |
ページ | 47-67 |
ページ数 | 21 |
ISBN(電子版) | 9789811529023 |
ISBN(印刷版) | 9789811529016 |
DOI | |
出版ステータス | 出版済み - 2020/01/01 |
ASJC Scopus 主題領域
- 薬理学、毒性学および薬学一般
- 神経科学一般
- 農業および生物科学一般
- 医学一般
- 心理学一般