SIRT5 mutants reveal the role of conserved asparagine and glutamine residues in the NAD⁺-binding pocket

Keyphrases

• Nicotinamide Adenine Dinucleotide (NAD+) 100%
• Binding Pocket 100%
• Asparagine 100%
• Glutamine 100%
• Sirtuin 5 (SIRT5) 100%
• Desuccinylation 50%
• Sirtuins 25%
• Amino Acid Substitution 25%
• Binding Residues 25%
• Kinetic Analysis 25%
• X-ray Crystallography 25%
• Lysine Residue 25%
• Catalytic Residues 25%
• Hydrophobic Amino Acids 25%
• Kcat 25%
• Catalytic Efficiency 25%

Biochemistry, Genetics and Molecular Biology

• Asparagine 100%
• Glutamine 100%
• SIRT5 100%
• Catalytic Efficiency 50%
• Wild Type 25%
• Sirtuin 25%
• Amino Acid Substitution 25%
• Active Site 25%
• Kinetics 25%
• X-Ray Crystallography 25%
• Lysine 25%