Siphonols A-E: Novel nitric oxide inhibitors from Orthosiphon stamineus of Indonesia

Suresh Awale; Yasuhiro Tezuka; Arjun H. Banskota; Shigetoshi Kadota

doi:10.1016/S0960-894X(02)00854-5

Siphonols A-E: Novel nitric oxide inhibitors from Orthosiphon stamineus of Indonesia

Suresh Awale, Yasuhiro Tezuka, Arjun H. Banskota, Shigetoshi Kadota^*

^*この論文の責任著者

和漢医薬学総合研究所研究開発部門資源開発分野（天然物創薬学領域）

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

36 被引用数 (Scopus)

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From the methanolic extract of Orthosiphon stamineus, four novel highly oxygenated isopimarane-type diterpenes named siphonols A-D (1-4) and a novel biogenetically interesting norisopimarane-type diterpene named siphonol E (5) were isolated. The new compounds 1-3 and 5 showed more potent inhibitory effects on the nitric oxide (NO) production in lipopolysaccharide (LPS)-activated macrophage-like J774.1 cells than a positive control N^G-monomethyl-L-arginine (L-NMMA). Siphonols A-E (1-5) represent the first examples of isopimaranes oxygenated at C-20.

本文言語	英語
ページ（範囲）	31-35
ページ数	5
ジャーナル	Bioorganic and Medicinal Chemistry Letters
巻	13
号	1
DOI	https://doi.org/10.1016/S0960-894X(02)00854-5
出版ステータス	出版済み - 2003/01/06

ASJC Scopus 主題領域

生化学
分子医療
分子生物学
薬科学
創薬
臨床生化学
有機化学

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10.1016/S0960-894X(02)00854-5

引用スタイル

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title = "Siphonols A-E: Novel nitric oxide inhibitors from Orthosiphon stamineus of Indonesia",

abstract = "From the methanolic extract of Orthosiphon stamineus, four novel highly oxygenated isopimarane-type diterpenes named siphonols A-D (1-4) and a novel biogenetically interesting norisopimarane-type diterpene named siphonol E (5) were isolated. The new compounds 1-3 and 5 showed more potent inhibitory effects on the nitric oxide (NO) production in lipopolysaccharide (LPS)-activated macrophage-like J774.1 cells than a positive control NG-monomethyl-L-arginine (L-NMMA). Siphonols A-E (1-5) represent the first examples of isopimaranes oxygenated at C-20.",

author = "Suresh Awale and Yasuhiro Tezuka and Banskota, {Arjun H.} and Shigetoshi Kadota",

note = "Funding Information: This work was supported in part by a Grant-in-Aid for International Scientific Research (No. 13576027) from The Ministry of Education, Culture, Sports, Science and Technology, Japan. ",

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T2 - Novel nitric oxide inhibitors from Orthosiphon stamineus of Indonesia

AU - Awale, Suresh

AU - Tezuka, Yasuhiro

AU - Banskota, Arjun H.

AU - Kadota, Shigetoshi

N1 - Funding Information: This work was supported in part by a Grant-in-Aid for International Scientific Research (No. 13576027) from The Ministry of Education, Culture, Sports, Science and Technology, Japan.

PY - 2003/1/6

Y1 - 2003/1/6

N2 - From the methanolic extract of Orthosiphon stamineus, four novel highly oxygenated isopimarane-type diterpenes named siphonols A-D (1-4) and a novel biogenetically interesting norisopimarane-type diterpene named siphonol E (5) were isolated. The new compounds 1-3 and 5 showed more potent inhibitory effects on the nitric oxide (NO) production in lipopolysaccharide (LPS)-activated macrophage-like J774.1 cells than a positive control NG-monomethyl-L-arginine (L-NMMA). Siphonols A-E (1-5) represent the first examples of isopimaranes oxygenated at C-20.

AB - From the methanolic extract of Orthosiphon stamineus, four novel highly oxygenated isopimarane-type diterpenes named siphonols A-D (1-4) and a novel biogenetically interesting norisopimarane-type diterpene named siphonol E (5) were isolated. The new compounds 1-3 and 5 showed more potent inhibitory effects on the nitric oxide (NO) production in lipopolysaccharide (LPS)-activated macrophage-like J774.1 cells than a positive control NG-monomethyl-L-arginine (L-NMMA). Siphonols A-E (1-5) represent the first examples of isopimaranes oxygenated at C-20.

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Siphonols A-E: Novel nitric oxide inhibitors from Orthosiphon stamineus of Indonesia

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