抄録
The natural product (+)-grandifloracin is a potent “anti-austerity” agent, able to suppress the ability of various pancreatic cancer cell lines to tolerate conditions of nutrient deprivation. Such anti-austerity agents represent a promising approach to cancer chemotherapy. Here we report the synthesis and biological evaluation of racemic analogues of grandifloracin bearing diverse sidechains, of which two show enhanced potency in comparison with the natural product. Additionally, several unexpected by-products containing modifications of the grandifloracin core were isolated, identified and similarly evaluated for biological activity.
本文言語 | 英語 |
---|---|
ページ(範囲) | 125-135 |
ページ数 | 11 |
ジャーナル | ChemMedChem |
巻 | 15 |
号 | 1 |
DOI | |
出版ステータス | 出版済み - 2020/01/07 |
ASJC Scopus 主題領域
- 創薬
- 薬理学、毒性学および薬学一般
- 分子医療
- 生化学
- 薬理学
- 有機化学