Self-assembly of cell springs using smooth muscle-like cells differentiated from multipotent cells

Amy Y. Hsiao*, Teru Okitsu, Hiroaki Onoe, Mahiro Kiyosawa, Hiroki Teramae, Shintaroh Iwanaga, Shigenori Miura, Tomohiko Kazama, Taro Matsumoto, Shoji Takeuchi

*この論文の責任著者

研究成果: 書籍の章/レポート/会議録会議への寄与査読

抄録

This paper describes the self-assembly of 'cell springs' using smooth muscle-like cells differentiated from multipotent dedifferentiated fat (DFAT) cells. Using a microfluidic co-axial device, DFAT cells suspended in extracellular matrix (ECM) mixture of fibrin and collagen were encapsulated within tubular alginate microfibers and formed into 3D fiber-shaped micro-constructs. Such DFAT cell fibers were then induced to differentiate into smooth muscle cells (SMCs) under various conditions. Upon differentiation induction, DFAT cell fibers spontaneously contracted into coiled spring structures within 3 days. After 3 weeks of differentiation, the differentiated DFAT cell fibers showed synchronized contraction upon electrical stimulation.

本文言語英語
ホスト出版物のタイトルIEEE 26th International Conference on Micro Electro Mechanical Systems, MEMS 2013
ページ71-73
ページ数3
DOI
出版ステータス出版済み - 2013
イベントIEEE 26th International Conference on Micro Electro Mechanical Systems, MEMS 2013 - Taipei, 台湾省、中華民国
継続期間: 2013/01/202013/01/24

出版物シリーズ

名前Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)
ISSN(印刷版)1084-6999

学会

学会IEEE 26th International Conference on Micro Electro Mechanical Systems, MEMS 2013
国/地域台湾省、中華民国
CityTaipei
Period2013/01/202013/01/24

ASJC Scopus 主題領域

  • 電子材料、光学材料、および磁性材料
  • 凝縮系物理学
  • 機械工学
  • 電子工学および電気工学

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