Secoorthosiphols A-C: Three highly oxygenated secoisopimarane-type diterpenes from Orthosiphon stamineus

Suresh Awale; Yasuhiro Tezuka; Seikichi Shimoji; Kazuhiko Taira; Shigetoshi Kadota

doi:10.1016/S0040-4039(02)00037-0

Secoorthosiphols A-C: Three highly oxygenated secoisopimarane-type diterpenes from Orthosiphon stamineus

Suresh Awale, Yasuhiro Tezuka, Seikichi Shimoji, Kazuhiko Taira, Shigetoshi Kadota^*

^*この論文の責任著者

和漢医薬学総合研究所研究開発部門資源開発分野（天然物創薬学領域）

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

20 被引用数 (Scopus)

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Three new highly oxygenated 2,3-secoisopimarane-type diterpenes, named secoorthosiphols A (1), B (2) and C (3), have been isolated as extremely minor constituents from the aerial parts of the Orthosiphon stamineus from Okinawa. A unique unprecedented structural feature of such a ring A opened system in newly isolated compounds was encountered for the first time in isopimarane-type diterpenes. Secoorthosiphol C (3) represents the first example of a biogenetically unique and unconventional secoisopimarane-type diterpene having a cyano group.

本文言語	英語
ページ（範囲）	1473-1475
ページ数	3
ジャーナル	Tetrahedron Letters
巻	43
号	8
DOI	https://doi.org/10.1016/S0040-4039(02)00037-0
出版ステータス	出版済み - 2002/02/18

ASJC Scopus 主題領域

生化学
創薬
有機化学

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10.1016/S0040-4039(02)00037-0

引用スタイル

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title = "Secoorthosiphols A-C: Three highly oxygenated secoisopimarane-type diterpenes from Orthosiphon stamineus",

abstract = "Three new highly oxygenated 2,3-secoisopimarane-type diterpenes, named secoorthosiphols A (1), B (2) and C (3), have been isolated as extremely minor constituents from the aerial parts of the Orthosiphon stamineus from Okinawa. A unique unprecedented structural feature of such a ring A opened system in newly isolated compounds was encountered for the first time in isopimarane-type diterpenes. Secoorthosiphol C (3) represents the first example of a biogenetically unique and unconventional secoisopimarane-type diterpene having a cyano group.",

author = "Suresh Awale and Yasuhiro Tezuka and Seikichi Shimoji and Kazuhiko Taira and Shigetoshi Kadota",

note = "Funding Information: This work was supported in part by a Grant-in-Aid for International Scientific Research (No.13576027) from The Ministry of Education, Culture, Sports, Science and Technology, Japan.",

year = "2002",

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doi = "10.1016/S0040-4039(02)00037-0",

language = "英語",

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T2 - Three highly oxygenated secoisopimarane-type diterpenes from Orthosiphon stamineus

AU - Awale, Suresh

AU - Tezuka, Yasuhiro

AU - Shimoji, Seikichi

AU - Taira, Kazuhiko

AU - Kadota, Shigetoshi

N1 - Funding Information: This work was supported in part by a Grant-in-Aid for International Scientific Research (No.13576027) from The Ministry of Education, Culture, Sports, Science and Technology, Japan.

PY - 2002/2/18

Y1 - 2002/2/18

N2 - Three new highly oxygenated 2,3-secoisopimarane-type diterpenes, named secoorthosiphols A (1), B (2) and C (3), have been isolated as extremely minor constituents from the aerial parts of the Orthosiphon stamineus from Okinawa. A unique unprecedented structural feature of such a ring A opened system in newly isolated compounds was encountered for the first time in isopimarane-type diterpenes. Secoorthosiphol C (3) represents the first example of a biogenetically unique and unconventional secoisopimarane-type diterpene having a cyano group.

AB - Three new highly oxygenated 2,3-secoisopimarane-type diterpenes, named secoorthosiphols A (1), B (2) and C (3), have been isolated as extremely minor constituents from the aerial parts of the Orthosiphon stamineus from Okinawa. A unique unprecedented structural feature of such a ring A opened system in newly isolated compounds was encountered for the first time in isopimarane-type diterpenes. Secoorthosiphol C (3) represents the first example of a biogenetically unique and unconventional secoisopimarane-type diterpene having a cyano group.

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U2 - 10.1016/S0040-4039(02)00037-0

DO - 10.1016/S0040-4039(02)00037-0

M3 - 学術論文

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JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 8

ER -

Secoorthosiphols A-C: Three highly oxygenated secoisopimarane-type diterpenes from Orthosiphon stamineus

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