TY - JOUR
T1 - Seasonal Influence on Development of Antineutrophil Cytoplasmic Antibody–Associated Vasculitis
T2 - A Retrospective Cohort Study Conducted at Multiple Institutions in Japan (J-CANVAS)
AU - Yoshida, Yusuke
AU - Nakamoto, Naoki
AU - Oka, Naoya
AU - Kidoguchi, Genki
AU - Hosokawa, Yohei
AU - Araki, Kei
AU - Ishitoku, Michinori
AU - Watanabe, Hirofumi
AU - Sugimoto, Tomohiro
AU - Mokuda, Sho
AU - Kida, Takashi
AU - Yajima, Nobuyuki
AU - Omura, Satoshi
AU - Nakagomi, Daiki
AU - Abe, Yoshiyuki
AU - Kadoya, Masatoshi
AU - Takizawa, Naoho
AU - Nomura, Atsushi
AU - Kukida, Yuji
AU - Kondo, Naoya
AU - Yamano, Yasuhiko
AU - Yanagida, Takuya
AU - Endo, Koji
AU - Matsui, Kiyoshi
AU - Takeuchi, Tohru
AU - Ichinose, Kunihiro
AU - Kato, Masaru
AU - Yanai, Ryo
AU - Matsuo, Yusuke
AU - Shimojima, Yasuhiro
AU - Nishioka, Ryo
AU - Okazaki, Ryota
AU - Takata, Tomoaki
AU - Ito, Takafumi
AU - Moriyama, Mayuko
AU - Takatani, Ayuko
AU - Miyawaki, Yoshia
AU - Ito-Ihara, Toshiko
AU - Kawaguchi, Takashi
AU - Kawahito, Yutaka
AU - Hirata, Shintaro
N1 - Publisher Copyright:
© 2023 The Journal of Rheumatology.
PY - 2023/9/29
Y1 - 2023/9/29
N2 - Objective. To clarify seasonal and other environmental effects on the onset of antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis (AAV). Methods. We enrolled patients with new-onset eosinophilic granulomatosis with polyangiitis (EGPA), microscopic polyangiitis (MPA), and granulomatosis with polyangiitis (GPA) registered in the database of a Japanese multicenter cohort study. We investigated the relationship between environmental factors and clinical characteristics. Seasons were divided into 4 (spring, summer, autumn, and winter), and the seasonal differences in AAV onset were analyzed using Pearson chi-square test, with an expected probability of 25% for each season. Results. A total of 454 patients were enrolled, with a mean age of 70.9 years and a female proportion of 55.5%. Overall, 74, 291, and 89 patients were classified as having EGPA, MPA, and GPA, respectively. Positivity for myeloperoxidase (MPO)-ANCA and proteinase 3 (PR3)-ANCA was observed in 355 and 46 patients, respectively. Overall, the seasonality of AAV onset significantly deviated from the expected 25% for each season (P = 0.001), and its onset was less frequently observed in autumn. In ANCA serotypes, seasonality was significant in patients with MPO-ANCA (P < 0.001), but not in those with PR3-ANCA (P = 0.97). Additionally, rural residency of patients with AAV was associated with PR3-ANCA positivity and biopsy-proven pulmonary vasculitis. Conclusion. The onset of AAV was influenced by seasonal variations and was less frequently observed in autumn. In contrast, the occurrence of PR3-ANCA was triggered, not by season, but by rural residency.
AB - Objective. To clarify seasonal and other environmental effects on the onset of antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis (AAV). Methods. We enrolled patients with new-onset eosinophilic granulomatosis with polyangiitis (EGPA), microscopic polyangiitis (MPA), and granulomatosis with polyangiitis (GPA) registered in the database of a Japanese multicenter cohort study. We investigated the relationship between environmental factors and clinical characteristics. Seasons were divided into 4 (spring, summer, autumn, and winter), and the seasonal differences in AAV onset were analyzed using Pearson chi-square test, with an expected probability of 25% for each season. Results. A total of 454 patients were enrolled, with a mean age of 70.9 years and a female proportion of 55.5%. Overall, 74, 291, and 89 patients were classified as having EGPA, MPA, and GPA, respectively. Positivity for myeloperoxidase (MPO)-ANCA and proteinase 3 (PR3)-ANCA was observed in 355 and 46 patients, respectively. Overall, the seasonality of AAV onset significantly deviated from the expected 25% for each season (P = 0.001), and its onset was less frequently observed in autumn. In ANCA serotypes, seasonality was significant in patients with MPO-ANCA (P < 0.001), but not in those with PR3-ANCA (P = 0.97). Additionally, rural residency of patients with AAV was associated with PR3-ANCA positivity and biopsy-proven pulmonary vasculitis. Conclusion. The onset of AAV was influenced by seasonal variations and was less frequently observed in autumn. In contrast, the occurrence of PR3-ANCA was triggered, not by season, but by rural residency.
KW - antineutrophil cytoplasmic antibody
KW - antineutrophil cytoplasmic antibody–associated vasculitis
KW - eosinophilic granulomatosis with polyangiitis
KW - granulomatosis with polyangiitis
KW - microscopic polyangiitis
KW - seasonal variation
UR - http://www.scopus.com/inward/record.url?scp=85169624894&partnerID=8YFLogxK
U2 - 10.3899/jrheum.2023-0040
DO - 10.3899/jrheum.2023-0040
M3 - 学術論文
C2 - 37263656
AN - SCOPUS:85169624894
SN - 0315-162X
VL - 50
SP - 1152
EP - 1158
JO - Journal of Rheumatology
JF - Journal of Rheumatology
IS - 9
ER -