Screening of Chinese and Mongolian herbal drugs for anti-human immunodeficiency virus type 1 (HIV-1) activity

Chao Mei Ma; Norio Nakamura; Hirotsugu Miyashiro; Masao Hattori; Katsuko Komatsu; Takuya Kawahata; Toru Otake

doi:10.1002/ptr.922

Screening of Chinese and Mongolian herbal drugs for anti-human immunodeficiency virus type 1 (HIV-1) activity

Chao Mei Ma, Norio Nakamura, Hirotsugu Miyashiro, Masao Hattori^*, Katsuko Komatsu, Takuya Kawahata, Toru Otake

^*この論文の責任著者

和漢医薬学総合研究所研究開発部門資源開発分野（資源科学領域）

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

34 被引用数 (Scopus)

抄録

Water and methanol extracts of 30 Chinese and Mongolian medicinal plants were tested for their human immunodeficiency virus type-1 (HIV-1) inhibitory activity. Of the 60 extracts, 23 showed anti-HIV activity. Bioassay-guided fractionation of one of the most active extracts, the methanol extract of the root tuber of Stephania cepharantha, led to the isolation of two alkaloids, aromoline and FK-3000 as potent inhibitory substances. They completely inhibited the cytopathic effects of HIV-1 on MT-4 cells at 31.3 and 7.8 μg/mL, respectively.

本文言語	英語
ページ（範囲）	186-189
ページ数	4
ジャーナル	Phytotherapy Research
巻	16
号	2
DOI	https://doi.org/10.1002/ptr.922
出版ステータス	出版済み - 2002

ASJC Scopus 主題領域

薬理学

UN SDG

この成果は、次の持続可能な開発目標に貢献しています

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10.1002/ptr.922

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title = "Screening of Chinese and Mongolian herbal drugs for anti-human immunodeficiency virus type 1 (HIV-1) activity",

abstract = "Water and methanol extracts of 30 Chinese and Mongolian medicinal plants were tested for their human immunodeficiency virus type-1 (HIV-1) inhibitory activity. Of the 60 extracts, 23 showed anti-HIV activity. Bioassay-guided fractionation of one of the most active extracts, the methanol extract of the root tuber of Stephania cepharantha, led to the isolation of two alkaloids, aromoline and FK-3000 as potent inhibitory substances. They completely inhibited the cytopathic effects of HIV-1 on MT-4 cells at 31.3 and 7.8 μg/mL, respectively.",

keywords = "Anti-HIV-1 activity, Aromoline, FK-3000, Stephania cepharantha",

author = "Ma, {Chao Mei} and Norio Nakamura and Hirotsugu Miyashiro and Masao Hattori and Katsuko Komatsu and Takuya Kawahata and Toru Otake",

year = "2002",

doi = "10.1002/ptr.922",

language = "英語",

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journal = "Phytotherapy Research",

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T1 - Screening of Chinese and Mongolian herbal drugs for anti-human immunodeficiency virus type 1 (HIV-1) activity

AU - Ma, Chao Mei

AU - Nakamura, Norio

AU - Miyashiro, Hirotsugu

AU - Hattori, Masao

AU - Komatsu, Katsuko

AU - Kawahata, Takuya

AU - Otake, Toru

PY - 2002

Y1 - 2002

N2 - Water and methanol extracts of 30 Chinese and Mongolian medicinal plants were tested for their human immunodeficiency virus type-1 (HIV-1) inhibitory activity. Of the 60 extracts, 23 showed anti-HIV activity. Bioassay-guided fractionation of one of the most active extracts, the methanol extract of the root tuber of Stephania cepharantha, led to the isolation of two alkaloids, aromoline and FK-3000 as potent inhibitory substances. They completely inhibited the cytopathic effects of HIV-1 on MT-4 cells at 31.3 and 7.8 μg/mL, respectively.

AB - Water and methanol extracts of 30 Chinese and Mongolian medicinal plants were tested for their human immunodeficiency virus type-1 (HIV-1) inhibitory activity. Of the 60 extracts, 23 showed anti-HIV activity. Bioassay-guided fractionation of one of the most active extracts, the methanol extract of the root tuber of Stephania cepharantha, led to the isolation of two alkaloids, aromoline and FK-3000 as potent inhibitory substances. They completely inhibited the cytopathic effects of HIV-1 on MT-4 cells at 31.3 and 7.8 μg/mL, respectively.

KW - Anti-HIV-1 activity

KW - Aromoline

KW - FK-3000

KW - Stephania cepharantha

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U2 - 10.1002/ptr.922

DO - 10.1002/ptr.922

M3 - 学術論文

C2 - 11933126

AN - SCOPUS:0036221009

SN - 0951-418X

VL - 16

SP - 186

EP - 189

JO - Phytotherapy Research

JF - Phytotherapy Research

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Screening of Chinese and Mongolian herbal drugs for anti-human immunodeficiency virus type 1 (HIV-1) activity

抄録

ASJC Scopus 主題領域

UN SDG

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