Role of Paternal Antigen-Specific Treg Cells in Successful Implantation

Shigeru Saito*, Tomoko Shima, Akitoshi Nakashima, Kumiko Inada, Osamu Yoshino

*この論文の責任著者

研究成果: ジャーナルへの寄稿総説査読

35 被引用数 (Scopus)

抄録

Maternal lymphocytes recognize fetal antigens, so tolerance is necessary to prevent rejection. Seminal plasma is important for induction of paternal antigen-specific Treg cells in the uterine draining lymph nodes and the pregnant uterus. Elimination of Treg cells during implantation or early pregnancy induces implantation failure or fetal resorption in mice. Immunosuppressive therapy with an anti-TNF antibody or the immunosuppressive agent tacrolimus improves the pregnancy rate in women with repeated implantation failure and recurrent pregnancy loss of unknown etiology, suggesting that Treg cells play an essential role in successful implantation and pregnancy in humans.

本文言語英語
ページ(範囲)310-316
ページ数7
ジャーナルAmerican Journal of Reproductive Immunology
75
3
DOI
出版ステータス出版済み - 2016/03/01

ASJC Scopus 主題領域

  • 免疫アレルギー学
  • 免疫学
  • 生殖医学
  • 産婦人科学

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