TY - JOUR
T1 - Reproductive organ involvement in women undergoing radical cystectomy for urothelial bladder cancer
T2 - a nationwide multicenter study
AU - the Japan Urological Oncology Group
AU - Kato, Minoru
AU - Taoka, Rikiya
AU - Miki, Jun
AU - Saito, Ryoichi
AU - Fukuokaya, Wataru
AU - Matsui, Yoshiyuki
AU - Yamamoto, Shoma
AU - Matsue, Taisuke
AU - Hatakeyama, Shingo
AU - Kawahara, Takashi
AU - Matsuda, Ayumu
AU - Kawai, Taketo
AU - Sazuka, Tomokazu
AU - Sano, Takeshi
AU - Urabe, Fumihiko
AU - Kashima, Soki
AU - Naito, Hirohito
AU - Murakami, Yoji
AU - Miyake, Makito
AU - Daizumoto, Kei
AU - Matsushita, Yuto
AU - Hayashi, Takuji
AU - Inokuchi, Junichi
AU - Sugino, Yusuke
AU - Shiga, Kenichiro
AU - Yamaguchi, Noriya
AU - Yamamoto, Shingo
AU - Yasue, Keiji
AU - Abe, Takashige
AU - Nakanishi, Shotaro
AU - Hashine, Katsuyoshi
AU - Fujii, Masato
AU - Nishihara, Kiyoaki
AU - Matsumoto, Hiroaki
AU - Tatarano, Shuichi
AU - Wada, Koichiro
AU - Sekito, Sho
AU - Maruyama, Ryo
AU - Nishiyama, Naotaka
AU - Nishiyama, Hiroyuki
AU - Kitamura, Hiroshi
AU - Uchida, Junji
N1 - Publisher Copyright:
© The Author(s) under exclusive licence to Japan Society of Clinical Oncology 2024.
PY - 2024/12
Y1 - 2024/12
N2 - Background: Radical cystectomy in women generally includes the removal of the uterus, ovaries, and anterior vaginal wall, but the criteria for reproductive organ sparing are not clear. Methods: A total of 2674 patients with bladder cancer were retrospectively reviewed, having undergone cystectomy at this nationwide multicenter from January 2013 to December 2019. We evaluated the incidence of malignancy in reproductive organs in a cohort of 417 women and analyzed the clinicopathological features of reproductive organ involvement. Recurrence-free survival and overall survival were reported using Kaplan–Meier survival curves. Results: Median follow-up was 36.9 months. Of the 417 patients with urothelial carcinoma of the bladder, 325 underwent hysterectomy, and 92 had a spared uterus and anterior wall of the vagina. Twenty-nine (8.9%) patients exhibited reproductive organ involvement; this consisted of 22 (6.8%) uteri, 16 (4.9%) vaginas, and two (0.6%) ovaries. Incidental primary reproductive malignancies were found in only two (0.6%) patients. Recurrence-free survival and overall survival were significantly shorter in patients with reproductive organ involvement than in those without. Patients with reproductive organ involvement were more likely to have tumors with ≥ cT3 or sub-localization at the posterior/trigone/bladder neck. Conclusions: The risk of reproductive organ involvement cannot be ignored in women undergoing radical cystectomy for urothelial carcinoma of the bladder, therefore, the eligibility criteria for reproductive organ preservation should be considered carefully.
AB - Background: Radical cystectomy in women generally includes the removal of the uterus, ovaries, and anterior vaginal wall, but the criteria for reproductive organ sparing are not clear. Methods: A total of 2674 patients with bladder cancer were retrospectively reviewed, having undergone cystectomy at this nationwide multicenter from January 2013 to December 2019. We evaluated the incidence of malignancy in reproductive organs in a cohort of 417 women and analyzed the clinicopathological features of reproductive organ involvement. Recurrence-free survival and overall survival were reported using Kaplan–Meier survival curves. Results: Median follow-up was 36.9 months. Of the 417 patients with urothelial carcinoma of the bladder, 325 underwent hysterectomy, and 92 had a spared uterus and anterior wall of the vagina. Twenty-nine (8.9%) patients exhibited reproductive organ involvement; this consisted of 22 (6.8%) uteri, 16 (4.9%) vaginas, and two (0.6%) ovaries. Incidental primary reproductive malignancies were found in only two (0.6%) patients. Recurrence-free survival and overall survival were significantly shorter in patients with reproductive organ involvement than in those without. Patients with reproductive organ involvement were more likely to have tumors with ≥ cT3 or sub-localization at the posterior/trigone/bladder neck. Conclusions: The risk of reproductive organ involvement cannot be ignored in women undergoing radical cystectomy for urothelial carcinoma of the bladder, therefore, the eligibility criteria for reproductive organ preservation should be considered carefully.
KW - Bladder cancer
KW - Radical cystectomy
KW - Reproductive organ involvement
KW - Woman
UR - http://www.scopus.com/inward/record.url?scp=85205808764&partnerID=8YFLogxK
U2 - 10.1007/s10147-024-02636-7
DO - 10.1007/s10147-024-02636-7
M3 - 学術論文
C2 - 39379757
AN - SCOPUS:85205808764
SN - 1341-9625
VL - 29
SP - 1937
EP - 1945
JO - International Journal of Clinical Oncology
JF - International Journal of Clinical Oncology
IS - 12
ER -