抄録
Regulation of BSF-2/IL-6 production in peripheral mononuclear cells (MNC) was studied. BSF-2 mRNA expression in mitogen-stimulated MNC showed a biphasic response, the first peak around 4 h and the second peak around 48 h. This was caused by different kinetics of BSF-2 mRNA expression in distinct subpopulations of MNC; MΦ expressed BSF-2 mRNA at 5 h in the absence of any stimulation, and mitogen-stimulated T cells and B cells expressed BSF-2 mRNA 48 h after stimulation. Immunohistochemical staining of the cells with anti-BSF-2 antibody demonstrated that macrophages, T cells and B cells could produce BSF-2. T cells in peripheral MNC produced BSF-2 in the presence of MΦ. The requirement of macrophage for BSF-2 production in T cells could be replaced by TPA but not by IL-1 or BSF-2.
| 本文言語 | 英語 |
|---|---|
| ページ（範囲） | 1529-1535 |
| ページ数 | 7 |
| ジャーナル | Journal of Immunology |
| 巻 | 141 |
| 号 | 5 |
| 出版ステータス | 出版済み - 1988 |
ASJC Scopus 主題領域
- 免疫アレルギー学
- 免疫学