TY - JOUR
T1 - Recent advances in cannabinoid biochemistry and biotechnology
AU - Taura, Futoshi
AU - Tanaya, Ryosuke
AU - Sirikantaramas, Supaart
N1 - Publisher Copyright:
© 2019 Science Society of Thailand under Royal Patronage. All rights reserved.
PY - 2019
Y1 - 2019
N2 - Cannabinoids, produced only in Cannabis sativa, are meroterpenoid secondary metabolites composed of monoterpene and polyketide moieties. Numerous cannabinoids have been isolated, and their pharmacological studies and clinical trials have been extensively conducted. Consequently, in recent years, certain formulations containing ∆9-tetrahydrocannabinol, the psychoactive principle of marijuana, and its isomer cannabidiol have been approved as prescribed medicines for various refractory diseases in about 30 countries. In addition, recent pioneering studies using a set of biosynthetic genes have enabled synthetic biology and synthetic biochemistry approaches to access plant-derived cannabinoids and new-to-nature analogues without the need for plant breeding. This review introduces the history of cannabinoid biosynthetic studies, and focuses on the biotechnological applications of biosynthetic enzymes.
AB - Cannabinoids, produced only in Cannabis sativa, are meroterpenoid secondary metabolites composed of monoterpene and polyketide moieties. Numerous cannabinoids have been isolated, and their pharmacological studies and clinical trials have been extensively conducted. Consequently, in recent years, certain formulations containing ∆9-tetrahydrocannabinol, the psychoactive principle of marijuana, and its isomer cannabidiol have been approved as prescribed medicines for various refractory diseases in about 30 countries. In addition, recent pioneering studies using a set of biosynthetic genes have enabled synthetic biology and synthetic biochemistry approaches to access plant-derived cannabinoids and new-to-nature analogues without the need for plant breeding. This review introduces the history of cannabinoid biosynthetic studies, and focuses on the biotechnological applications of biosynthetic enzymes.
KW - Biosynthesis
KW - Cannabinoid
KW - Cannabis sativa
KW - Synthetic biochemistry
KW - Synthetic biology
UR - http://www.scopus.com/inward/record.url?scp=85078033568&partnerID=8YFLogxK
U2 - 10.2306/scienceasia1513-1874.2019.45.399
DO - 10.2306/scienceasia1513-1874.2019.45.399
M3 - 学術論文
AN - SCOPUS:85078033568
SN - 1513-1874
VL - 45
SP - 399
EP - 407
JO - ScienceAsia
JF - ScienceAsia
IS - 5
ER -