@inproceedings{a93daacc224d4bcf94dfe0589b993259,
title = "Raman endoscopy for real time monitoring of anticancer drug treatment in colorectal tumors of live model mice",
abstract = "The aim of the present study is to evaluate the capability of a miniaturized Raman endoscope (mRE) system to monitor the advancement of colorectal tumors in live model mice. The endoscope is narrow enough to observe the inside of the mouse colon under anesthesia. The mRE system allows to observe the tissues and to apply a miniaturized Raman probe for the measurement at any targeted point within the colon. Raman spectroscopy allows obtaining information about molecular composition without damaging the tissue (i.e., noninvasively). Continuous monitoring of the same tumor is carried out to study molecular alterations along with its advancement. The Raman spectra measured before and after the anticancer drug (5-FU) treatment indicated spectral changes in the tumor tissue. It suggests that the tumor is not cured but supposedly transformed to another tumor type after the treatment.",
keywords = "Anticancer drugs, Cancer advancement, Cancer mouse model, Colorectal cancer, Endoscopic Raman spectroscopy, In situ measurement",
author = "Akinori Taketani and Mika Ishigaki and Andriana, {Bibin Bintan} and Hidetoshi Sato",
year = "2014",
doi = "10.1117/12.2038939",
language = "英語",
isbn = "9780819498649",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
publisher = "SPIE",
booktitle = "Optical Diagnostics and Sensing XIV",
note = "Optical Diagnostics and Sensing XIV: Toward Point-of-Care Diagnostics ; Conference date: 03-02-2014 Through 06-02-2014",
}
