TY - JOUR
T1 - Quantitative trait loci for age-related memory dysfunction in SAMP8 and JF1 mice
AU - Isobe, Masaharu
AU - Tomobe, Koji
AU - Sawada, Masanobu
AU - Kondo, Ayako
AU - Kurosawa, Nobuyuki
AU - Nomura, Yasuyuki
N1 - Funding Information:
The authors wish to thank members of the Self-Employed Women’s Association for their support and Prof Anne Mills, Dr Amie Cullimore and Ms Mirai Chatterjee for stimulating review comments. Thanks to Ms Swati Vyas and Ms Dimple Save for their research assistance. This research was supported by the Department for International Development, UK.
PY - 2004/2/1
Y1 - 2004/2/1
N2 - The senescence-accelerated mouse (SAM) P8 strain exhibits severe age-related learning and memory deficits (LMD) well before the median age of survival. As a first step to clarify the genes involved in this deterioration, we have performed genetic analysis of SAMP8 using the whole genome scan for quantitative trait loci (QTLs) specifying the impairment in step-through passive avoidance response with F2 intercrosses of SAMP8 exhibiting short retention time (RT) and Japanese Fancy Mouse 1 (JF1) derived from Japanese wild mouse (Mus musculus molossinus) exhibiting normal long retention time. Genetic markers were typed at 113 loci spanning all chromosomes except the Y. Five loci have been identified with significant linkage to chromosomes 1, 12, 13 and 15 by interval mapping of 264 F2 mice. Three of them on chromosomes 1, 12, and 13 are due to SAMP8 background, while two of them on chromosome 15 are derived from JF1 background despite parental JF1 strain shows normal phenotype.
AB - The senescence-accelerated mouse (SAM) P8 strain exhibits severe age-related learning and memory deficits (LMD) well before the median age of survival. As a first step to clarify the genes involved in this deterioration, we have performed genetic analysis of SAMP8 using the whole genome scan for quantitative trait loci (QTLs) specifying the impairment in step-through passive avoidance response with F2 intercrosses of SAMP8 exhibiting short retention time (RT) and Japanese Fancy Mouse 1 (JF1) derived from Japanese wild mouse (Mus musculus molossinus) exhibiting normal long retention time. Genetic markers were typed at 113 loci spanning all chromosomes except the Y. Five loci have been identified with significant linkage to chromosomes 1, 12, 13 and 15 by interval mapping of 264 F2 mice. Three of them on chromosomes 1, 12, and 13 are due to SAMP8 background, while two of them on chromosome 15 are derived from JF1 background despite parental JF1 strain shows normal phenotype.
KW - Learning and memory deficits
KW - Quantitative test locus
KW - Senescence-accelerated mouse (SAM)
KW - Step-through passive avoidance test
UR - http://www.scopus.com/inward/record.url?scp=84887481555&partnerID=8YFLogxK
U2 - 10.1016/S0531-5131(03)01563-2
DO - 10.1016/S0531-5131(03)01563-2
M3 - 学術論文
AN - SCOPUS:84887481555
SN - 0531-5131
VL - 1260
SP - 29
EP - 34
JO - International Congress Series
JF - International Congress Series
IS - C
ER -