TY - JOUR
T1 - Protective effects of keishibukuryogan on the kidney of spontaneously diabetic WBN/Kob rats
AU - Nakagawa, Takako
AU - Goto, Hirozo
AU - Hikiami, Hiroaki
AU - Yokozawa, Takako
AU - Shibahara, Naotoshi
AU - Shimada, Yutaka
N1 - Funding Information:
This work was supported by the Kampou Science Foundation, and partially by a Grand-in-Aid for the 21st Century Program from the Ministry of Education, Culture, Sports, Science and Technology, Japan.
PY - 2007/3/21
Y1 - 2007/3/21
N2 - Keishibukuryogan, one of the traditional herbal formulations, is used clinically to improve blood circulation. It consists of the following five crude drugs: Cinnamomi Cortex, Poria, Moutan Cortex, Persicae Semen and Paeoniae Radix. In this study, the effects of keishibukuryogan against renal damage in spontaneously diabetic WBN/Kob rats were examined. Oral administration of keishibukuryogan significantly attenuated urinary protein excretion and serum creatinine levels. It did not affect body weight loss and blood glucose levels, but it suppressed renal and hepatic weights of WBN/Kob rats. Keishibukuryogan also reduced fibronectin and transforming growth factor β1 (TGF-β1) protein expression in the renal cortex. Furthermore, lipid peroxidation levels in both kidney and liver were significantly lower than those of untreated control WBN/Kob rats. Urinary excretion of 8-hydroxy-deoxyguanosine was suppressed by keishibukuryogan treatment. These results suggest that keishibukuryogan reduces oxidative stress by hyperglycemia, and that it protects renal function and suppresses fibronectin deposition induced by TGF-β1 production in WBN/Kob rats.
AB - Keishibukuryogan, one of the traditional herbal formulations, is used clinically to improve blood circulation. It consists of the following five crude drugs: Cinnamomi Cortex, Poria, Moutan Cortex, Persicae Semen and Paeoniae Radix. In this study, the effects of keishibukuryogan against renal damage in spontaneously diabetic WBN/Kob rats were examined. Oral administration of keishibukuryogan significantly attenuated urinary protein excretion and serum creatinine levels. It did not affect body weight loss and blood glucose levels, but it suppressed renal and hepatic weights of WBN/Kob rats. Keishibukuryogan also reduced fibronectin and transforming growth factor β1 (TGF-β1) protein expression in the renal cortex. Furthermore, lipid peroxidation levels in both kidney and liver were significantly lower than those of untreated control WBN/Kob rats. Urinary excretion of 8-hydroxy-deoxyguanosine was suppressed by keishibukuryogan treatment. These results suggest that keishibukuryogan reduces oxidative stress by hyperglycemia, and that it protects renal function and suppresses fibronectin deposition induced by TGF-β1 production in WBN/Kob rats.
KW - Diabetic nephropathy
KW - Fibronectin
KW - Keishibukuryogan
KW - Transforming growth factor β (TGF-β)
KW - WBN/Kob rat
UR - http://www.scopus.com/inward/record.url?scp=33847165208&partnerID=8YFLogxK
U2 - 10.1016/j.jep.2006.09.043
DO - 10.1016/j.jep.2006.09.043
M3 - 学術論文
C2 - 17123761
AN - SCOPUS:33847165208
SN - 0378-8741
VL - 110
SP - 311
EP - 317
JO - Journal of Ethnopharmacology
JF - Journal of Ethnopharmacology
IS - 2
ER -
