Prognostic significance of NANOG and KLF4 for breast cancer

Takuya Nagata*, Yutaka Shimada, Shinichi Sekine, Ryota Hori, Koshi Matsui, Tomoyuki Okumura, Shigeaki Sawada, Junya Fukuoka, Kazuhiro Tsukada

*この論文の責任著者

研究成果: ジャーナルへの寄稿学術論文査読

108 被引用数 (Scopus)

抄録

Background: Some of the induced pluripotent stem cell (iPS cell)-inducing factors have been reported to be expressed in breast cancer. The aim of the present study was to examine the relationship between the expression of iPS cell-inducing factors and the prognosis of breast cancer patients. Methods: In 100 breast cancer patients, the expression of c-MYC, KLF4, NANOG, OCT4, and SOX2 was determined by immunohistochemistry using a tissue microarray analysis. Results: Patients with strong expression of NANOG had significantly lower disease-free survival (DFS) and overall survival rates than those with weak expression of NANOG (P = 0.004 and 0.033, respectively). In contrast, patients with strong expression of KLF4 had better DFS (P = 0.014). Conclusions: Strong expression of NANOG is an indicator of a poor prognosis for breast cancer patients, whereas KLF4 is a favorable prognostic indicator. Our results suggest that NANOG stimulates the growth and metastasis of breast cancer cells, whereas KLF4 inhibits these processes.

本文言語英語
ページ(範囲)96-101
ページ数6
ジャーナルBreast Cancer
21
1
DOI
出版ステータス出版済み - 2014/01

ASJC Scopus 主題領域

  • 腫瘍学
  • 放射線学、核医学およびイメージング
  • 薬理学(医学)

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