Procalcitonin, brain natriuretic peptide and albumin as markers to predict prognosis in hospitalized older Japanese patients with a risk of infection

Toshihiro Higashikawa, Toru Ito, Tomohiko Ito, Takuro Mizuno, Keiichirou Ishigami, Kengo Kuroki, Naoto Maekawa, Daisuke Usuda, Michiteru Yoshida, Takuro Morita, Kazu Hamada, Hiroshi Yano, Kento Takeshima, Takatoshi Haraguchi, Shinya Yamada, Sohsuke Yamada, Tomoyuki Ushimoto, Ryusho Sangen, Toshihide Izumida, Jun KiyosawaTaisuke Ono, Masaharu Iguchi, Yukihiro Wato, Takeshi Nakahashi, Yuji Kasamaki, Akihiro Fukuda, Tsugiyasu Kanda, Shigeto Morimoto, Masashi Okuro*

*この論文の責任著者

研究成果: ジャーナルへの寄稿学術論文査読

抄録

Aim: Whether serum concentration of procalcitonin (PCT), brain natriuretic peptide (BNP) and albumin (Alb) have an association with the outcome of hospitalized older patients is unclear. We investigated clinical outcomes and any predictive factors in hospitalized Japanese older patients with a risk of infection. Methods: In the retrospective study, 820 Japanese patients were followed up for 30 days or until death. During the observation period, 656 patients survived and 164 patients died. The predictive factors of death were analyzed according to demographic and clinical variables. Results: The survival rate was decreased as the serum PCT increased from <0.5 to ≥10 ng/mL, as was also the case with BNP from <300 to ≥300 pg./mL, whereas low Alb (<2.5 g/dL) showed a lower survival rate than high Alb (≥2.5 g/dL; P < 0.01). Using the Cox regression model, the multivariable-adjusted hazard ratios (95% confidence interval) were as follows: PCT 0.5–2 versus <0.5 ng/mL: 1.61(1.04–2.49), PCT 2–10 versus <0.5 ng/mL: 1.91(1.15–3.16), PCT ≥10 versus <0.5 ng/mL: 2.90(1.84–4.59), high BNP 1.26 (0.89–1.76) and low Alb 0.68 (0.52–0.87). The mortality rate increased as the number of scores (PCT + BNP + Alb) increased. Conclusions: Concentration-dependent high PCT, high BNP and low Alb were positive risk factors associated with poor prognosis in hospitalized older patients with a risk of infection. Geriatr Gerontol Int 2024; 24: 571–576.

本文言語英語
ページ(範囲)571-576
ページ数6
ジャーナルGeriatrics and Gerontology International
24
6
DOI
出版ステータス出版済み - 2024/06

ASJC Scopus 主題領域

  • 健康(社会科学)
  • 老年学
  • 老年医学

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