TY - JOUR
T1 - Procalcitonin, brain natriuretic peptide and albumin as markers to predict prognosis in hospitalized older Japanese patients with a risk of infection
AU - Higashikawa, Toshihiro
AU - Ito, Toru
AU - Ito, Tomohiko
AU - Mizuno, Takuro
AU - Ishigami, Keiichirou
AU - Kuroki, Kengo
AU - Maekawa, Naoto
AU - Usuda, Daisuke
AU - Yoshida, Michiteru
AU - Morita, Takuro
AU - Hamada, Kazu
AU - Yano, Hiroshi
AU - Takeshima, Kento
AU - Haraguchi, Takatoshi
AU - Yamada, Shinya
AU - Yamada, Sohsuke
AU - Ushimoto, Tomoyuki
AU - Sangen, Ryusho
AU - Izumida, Toshihide
AU - Kiyosawa, Jun
AU - Ono, Taisuke
AU - Iguchi, Masaharu
AU - Wato, Yukihiro
AU - Nakahashi, Takeshi
AU - Kasamaki, Yuji
AU - Fukuda, Akihiro
AU - Kanda, Tsugiyasu
AU - Morimoto, Shigeto
AU - Okuro, Masashi
N1 - Publisher Copyright:
© 2024 Japan Geriatrics Society.
PY - 2024/6
Y1 - 2024/6
N2 - Aim: Whether serum concentration of procalcitonin (PCT), brain natriuretic peptide (BNP) and albumin (Alb) have an association with the outcome of hospitalized older patients is unclear. We investigated clinical outcomes and any predictive factors in hospitalized Japanese older patients with a risk of infection. Methods: In the retrospective study, 820 Japanese patients were followed up for 30 days or until death. During the observation period, 656 patients survived and 164 patients died. The predictive factors of death were analyzed according to demographic and clinical variables. Results: The survival rate was decreased as the serum PCT increased from <0.5 to ≥10 ng/mL, as was also the case with BNP from <300 to ≥300 pg./mL, whereas low Alb (<2.5 g/dL) showed a lower survival rate than high Alb (≥2.5 g/dL; P < 0.01). Using the Cox regression model, the multivariable-adjusted hazard ratios (95% confidence interval) were as follows: PCT 0.5–2 versus <0.5 ng/mL: 1.61(1.04–2.49), PCT 2–10 versus <0.5 ng/mL: 1.91(1.15–3.16), PCT ≥10 versus <0.5 ng/mL: 2.90(1.84–4.59), high BNP 1.26 (0.89–1.76) and low Alb 0.68 (0.52–0.87). The mortality rate increased as the number of scores (PCT + BNP + Alb) increased. Conclusions: Concentration-dependent high PCT, high BNP and low Alb were positive risk factors associated with poor prognosis in hospitalized older patients with a risk of infection. Geriatr Gerontol Int 2024; 24: 571–576.
AB - Aim: Whether serum concentration of procalcitonin (PCT), brain natriuretic peptide (BNP) and albumin (Alb) have an association with the outcome of hospitalized older patients is unclear. We investigated clinical outcomes and any predictive factors in hospitalized Japanese older patients with a risk of infection. Methods: In the retrospective study, 820 Japanese patients were followed up for 30 days or until death. During the observation period, 656 patients survived and 164 patients died. The predictive factors of death were analyzed according to demographic and clinical variables. Results: The survival rate was decreased as the serum PCT increased from <0.5 to ≥10 ng/mL, as was also the case with BNP from <300 to ≥300 pg./mL, whereas low Alb (<2.5 g/dL) showed a lower survival rate than high Alb (≥2.5 g/dL; P < 0.01). Using the Cox regression model, the multivariable-adjusted hazard ratios (95% confidence interval) were as follows: PCT 0.5–2 versus <0.5 ng/mL: 1.61(1.04–2.49), PCT 2–10 versus <0.5 ng/mL: 1.91(1.15–3.16), PCT ≥10 versus <0.5 ng/mL: 2.90(1.84–4.59), high BNP 1.26 (0.89–1.76) and low Alb 0.68 (0.52–0.87). The mortality rate increased as the number of scores (PCT + BNP + Alb) increased. Conclusions: Concentration-dependent high PCT, high BNP and low Alb were positive risk factors associated with poor prognosis in hospitalized older patients with a risk of infection. Geriatr Gerontol Int 2024; 24: 571–576.
KW - albumin
KW - brain natriuretic peptide
KW - hospitalization
KW - procalcitonin
UR - http://www.scopus.com/inward/record.url?scp=85192196104&partnerID=8YFLogxK
U2 - 10.1111/ggi.14887
DO - 10.1111/ggi.14887
M3 - 学術論文
C2 - 38690756
AN - SCOPUS:85192196104
SN - 1444-1586
VL - 24
SP - 571
EP - 576
JO - Geriatrics and Gerontology International
JF - Geriatrics and Gerontology International
IS - 6
ER -