Primary hepatic neuroendocrine carcinoma

An 84-year-old woman was admitted to our hospital because of palpable abdominal tumor and poor dietary intake. Examination revealed a hypervascular tumor measuring 15 cm with cystic change in the lateral section of the liver. She was given a diagnosis of atypical primary malignant liver tumor and underwent left lateral sectionectomy. Pathologically, tumor cells with ambiguous cytoplasm and round nuclei formed a solid nest, and in the central part of the tumor, extensive necrosis was observed. Immunohistologically, synaptophysin, CD 56, NSE were positive. The Ki 67 index was over 90%, which was equivalent to Grade 3 (NEC) in the WHO classification revised in 2010. Since there were no other lesions that were suspected to be the primary site other than in the liver, it was diagnosed as primary hepatic neuroendocrine carcinoma. After the operation, she was discharged without complications on postoperative day 17. She has been followed postoperatively without recurrence for 2 years.