Pre-conception status, obstetric outcome and use of medications during pregnancy of systemic lupus erythematosus (SLE), rheumatoid arthritis (RA) and inflammatory bowel disease (IBD) in Japan: Multi-center retrospective descriptive study

for The Ministry of Health Labour and Welfare Working Group for “Guideline for The Treatment of Rheumatoid Arthritis or Inflammatory Bowel Disease Bearing Women in Child-bearing Age”

研究成果: ジャーナルへの寄稿学術論文査読

26 被引用数 (Scopus)

抄録

Objective: To describe the pre-conception status, pregnancy outcomes, and medication prevalence in systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), Crohn’s disease (CD), and ulcerative colitis (UC). Methods: E-mail-based questionnaire survey for the Japan Maternal Fetal Intensive Care Unit Network hospitals inquiring prevalence and clinical features of SLE, RA, CD and UC complicated pregnancies for 2 years. Results: The number of SLE, RA, CD and UC among 69,810 deliveries was 184, 139, 27 and 178, respectively. Less than half of pregnancies were planned. Assisted reproductive technology (ART) pregnancy rates were higher in SLE, RA and UC than in the general population (11.4, 23.0 and 7.4 vs 5.1%, p <.001 each). Preterm delivery, preeclampsia, and fetal growth restriction (FGR) were more frequent in SLE than in the general population (39.4 vs. 5.6% p <.001, 15.0 vs. 6.0% p <.001, 12.9 vs 4.2% p <.001). Prevalence of preterm delivery in RA and UC (27.5 vs. 5.6% p <.001, 11.3 vs. 5.6% p <.05) and FGR in CD (28.6 vs. 4.2% p <.001) was also higher than that in the general population. Conclusion: SLE, RA, CD, and UC complicated pregnancies were at high risks of obstetric adverse outcome. High ART rates necessitate pre-conception counseling in SLE, RA, and UC pregnancies.

本文言語英語
ページ(範囲)852-861
ページ数10
ジャーナルModern Rheumatology
30
5
DOI
出版ステータス出版済み - 2020/09/02

ASJC Scopus 主題領域

  • 医学一般

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