Possible involvement of glucose transporter 3 and 4 in esophageal leiomyoma with unusual high uptake of fluorine-18-fluorodeoxyglucose: Three case reports

Yutaka Shimada*, Tomoyuki Okumura, Ryota Hori, Makoto Moriyama, Shinichi Sekine, Takuya Nagata, Kazuhiro Nomoto, Junya Fukuoka, Kenichi Tazawa, Kazuhiro Tsukada

*この論文の責任著者

研究成果: ジャーナルへの寄稿学術論文査読

2 被引用数 (Scopus)

抄録

There were esophageal benign leiomyomas that showed unusual uptake of fluorine-18-fluorodeoxyglucose (FDG). Three patients received enucleation or resection of esophageal submucosal tumors and these were confirmed as benign leiomyomas pathologically. Preoperative FDG-PET examination of the two patients revealed that maximum standardized uptake values (SUVmax) of the tumor were 5.83 and 5.57. Both tumors had strong expression of glucose transporter (Glut)-3 and Glut-4. The other one patient showed low uptake of FDG and weak expression of Glut-3 and Glut-4. Interestingly, all three tumors had negative expression of Glut-1 and Glut-2. Furthermore, cultured leiomyoma cells (TYLeio-3) from the patients with high uptake of FDG had strong expression of Glut-3, weak expression of Glut-4 and no expression of Glut-1. Our results suggested that the expression of Glut-3 and Glut-4, but not Glut-1, may be one of the reasons for unusual uptake of FDG in benign esophageal leiomyoma.

本文言語英語
ページ(範囲)34-41
ページ数8
ジャーナルEsophagus
10
1
DOI
出版ステータス出版済み - 2013/03

ASJC Scopus 主題領域

  • 消化器病学

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