抄録
Platinum nanoparticles (nano-Pts) possess anti-inflammatory activity and the ability to scavenge superoxides anions and peroxides, indicating that they can act as superoxide dismutase (SOD)/catalase mimetics. These potentials seem useful in the protection and/or the amelioration of oxidative stress-associated pathologies. Recent studies investigated the effects of poly acrylic acid-capped nano-Pts on ultraviolet (UV)-induced inflammation and the underlying molecular mechanisms in keratinocytes. Nano-Pts effectively protect against UV-induced inflammation in keratinocytes by decreasing reactive oxygen species (ROS) production. In addition, nano-Pts significantly inhibit RANKL-stimulated osteoclastogenesis in RAW 264.7 cells by the suppression of ROS. Moreover, the intranasal administration of nano-Pts prior to cigarette smoke exposure has been shown to inhibit inflammation in the lungs of mice. On the other hand, nano-Pts resulted in hyperthermia-desensitization in lymphoma cells where the signaling pathways involved in apoptosis are inhibited by nano-Pts. This chapter reviews the latest findings regarding the effects of nano-Pts on inflammatory responses.
本文言語 | 英語 |
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ホスト出版物のタイトル | Platinum |
ホスト出版物のサブタイトル | Compounds, Production and Applications |
出版社 | Nova Science Publishers, Inc. |
ページ | 115-122 |
ページ数 | 8 |
ISBN(印刷版) | 9781622579396 |
出版ステータス | 出版済み - 2013/01 |
ASJC Scopus 主題領域
- 化学工学一般