Platinum nanoparticles and inflammation

Platinum nanoparticles (nano-Pts) possess anti-inflammatory activity and the ability to scavenge superoxides anions and peroxides, indicating that they can act as superoxide dismutase (SOD)/catalase mimetics. These potentials seem useful in the protection and/or the amelioration of oxidative stress-associated pathologies. Recent studies investigated the effects of poly acrylic acid-capped nano-Pts on ultraviolet (UV)-induced inflammation and the underlying molecular mechanisms in keratinocytes. Nano-Pts effectively protect against UV-induced inflammation in keratinocytes by decreasing reactive oxygen species (ROS) production. In addition, nano-Pts significantly inhibit RANKL-stimulated osteoclastogenesis in RAW 264.7 cells by the suppression of ROS. Moreover, the intranasal administration of nano-Pts prior to cigarette smoke exposure has been shown to inhibit inflammation in the lungs of mice. On the other hand, nano-Pts resulted in hyperthermia-desensitization in lymphoma cells where the signaling pathways involved in apoptosis are inhibited by nano-Pts. This chapter reviews the latest findings regarding the effects of nano-Pts on inflammatory responses.