Phytochemical and cytotoxic studies on the leaves of Calotropis gigantea

Khang D.H. Nguyen; Phu H. Dang; Hai X. Nguyen; Mai T.T. Nguyen; Suresh Awale; Nhan T. Nguyen

doi:10.1016/j.bmcl.2017.04.087

Phytochemical and cytotoxic studies on the leaves of Calotropis gigantea

Khang D.H. Nguyen, Phu H. Dang, Hai X. Nguyen, Mai T.T. Nguyen, Suresh Awale^*, Nhan T. Nguyen

^*この論文の責任著者

和漢医薬学総合研究所研究開発部門資源開発分野（天然物創薬学領域）

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

30 被引用数 (Scopus)

抄録

A new lignan, 9′-methoxypinoresinol (1), and two new glycosylated 5-hydroxymethylfurfurals, calofurfuralside A (2), and calofurfuralside B (3), together with nine known compounds (4–12) have been isolated from the active fractions, CHCl₃ (IC₅₀, 0.32 μg mL⁻¹) and EtOAc (IC₅₀, 0.55 μg mL⁻¹) fractions of the leaves of Calotropis gigantea. Their structures were elucidated based on NMR and MS data. Among the isolated compounds, compounds 1 and 9 exhibited potent cytotoxicity against PANC-1 human pancreatic cancer cell line under the normoglycemic condition with IC₅₀ values of 3.7 and 3.3 μM, respectively. 9′-Methoxypinoresinol (1) significantly inhibited the colony formation of PANC-1 cells in a concentration-dependent manner.

本文言語	英語
ページ（範囲）	2902-2906
ページ数	5
ジャーナル	Bioorganic and Medicinal Chemistry Letters
巻	27
号	13
DOI	https://doi.org/10.1016/j.bmcl.2017.04.087
出版ステータス	出版済み - 2017

ASJC Scopus 主題領域

生化学
分子医療
分子生物学
薬科学
創薬
臨床生化学
有機化学

UN SDG

この成果は、次の持続可能な開発目標に貢献しています

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10.1016/j.bmcl.2017.04.087

引用スタイル

@article{8e7df5a6c05442e7bcf5c6377a816385,

title = "Phytochemical and cytotoxic studies on the leaves of Calotropis gigantea",

abstract = "A new lignan, 9′-methoxypinoresinol (1), and two new glycosylated 5-hydroxymethylfurfurals, calofurfuralside A (2), and calofurfuralside B (3), together with nine known compounds (4–12) have been isolated from the active fractions, CHCl3 (IC50, 0.32 μg mL−1) and EtOAc (IC50, 0.55 μg mL−1) fractions of the leaves of Calotropis gigantea. Their structures were elucidated based on NMR and MS data. Among the isolated compounds, compounds 1 and 9 exhibited potent cytotoxicity against PANC-1 human pancreatic cancer cell line under the normoglycemic condition with IC50 values of 3.7 and 3.3 μM, respectively. 9′-Methoxypinoresinol (1) significantly inhibited the colony formation of PANC-1 cells in a concentration-dependent manner.",

keywords = "9′-Methoxypinoresinol, Asclepiadaceae, Calotropis gigantea, Glycosylated 5-hydroxymethylfurfural, PANC-1 human pancreatic cancer cell line",

author = "Nguyen, {Khang D.H.} and Dang, {Phu H.} and Nguyen, {Hai X.} and Nguyen, {Mai T.T.} and Suresh Awale and Nguyen, {Nhan T.}",

note = "Publisher Copyright: {\textcopyright} 2017 Elsevier Ltd",

year = "2017",

doi = "10.1016/j.bmcl.2017.04.087",

language = "英語",

volume = "27",

pages = "2902--2906",

journal = "Bioorganic and Medicinal Chemistry Letters",

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TY - JOUR

T1 - Phytochemical and cytotoxic studies on the leaves of Calotropis gigantea

AU - Nguyen, Khang D.H.

AU - Dang, Phu H.

AU - Nguyen, Hai X.

AU - Nguyen, Mai T.T.

AU - Awale, Suresh

AU - Nguyen, Nhan T.

PY - 2017

Y1 - 2017

N2 - A new lignan, 9′-methoxypinoresinol (1), and two new glycosylated 5-hydroxymethylfurfurals, calofurfuralside A (2), and calofurfuralside B (3), together with nine known compounds (4–12) have been isolated from the active fractions, CHCl3 (IC50, 0.32 μg mL−1) and EtOAc (IC50, 0.55 μg mL−1) fractions of the leaves of Calotropis gigantea. Their structures were elucidated based on NMR and MS data. Among the isolated compounds, compounds 1 and 9 exhibited potent cytotoxicity against PANC-1 human pancreatic cancer cell line under the normoglycemic condition with IC50 values of 3.7 and 3.3 μM, respectively. 9′-Methoxypinoresinol (1) significantly inhibited the colony formation of PANC-1 cells in a concentration-dependent manner.

AB - A new lignan, 9′-methoxypinoresinol (1), and two new glycosylated 5-hydroxymethylfurfurals, calofurfuralside A (2), and calofurfuralside B (3), together with nine known compounds (4–12) have been isolated from the active fractions, CHCl3 (IC50, 0.32 μg mL−1) and EtOAc (IC50, 0.55 μg mL−1) fractions of the leaves of Calotropis gigantea. Their structures were elucidated based on NMR and MS data. Among the isolated compounds, compounds 1 and 9 exhibited potent cytotoxicity against PANC-1 human pancreatic cancer cell line under the normoglycemic condition with IC50 values of 3.7 and 3.3 μM, respectively. 9′-Methoxypinoresinol (1) significantly inhibited the colony formation of PANC-1 cells in a concentration-dependent manner.

KW - 9′-Methoxypinoresinol

KW - Asclepiadaceae

KW - Calotropis gigantea

KW - Glycosylated 5-hydroxymethylfurfural

KW - PANC-1 human pancreatic cancer cell line

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U2 - 10.1016/j.bmcl.2017.04.087

DO - 10.1016/j.bmcl.2017.04.087

M3 - 学術論文

C2 - 28495081

AN - SCOPUS:85019049157

SN - 0960-894X

VL - 27

SP - 2902

EP - 2906

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 13

ER -

Phytochemical and cytotoxic studies on the leaves of Calotropis gigantea

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ASJC Scopus 主題領域

UN SDG

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