Phenotypes of IRS-2 deficient mice produced by reproductive technology are stable

Haruo Hashimoto; Toshiro Arai; Yasuyuki Ohnishi; Tomoo Eto; Mamoru Ito; Kyoji Hioki; Ryo Suzuki; Toshimasa Yamauchi; Mitsuru Ohsugi; Muneo Saito; Yoshito Ueyama; Kazuyuki Tobe; Takashi Kadowaki; Norikazu Tamaoki; Kinori Kosaka

doi:10.1538/expanim.56.149

Phenotypes of IRS-2 deficient mice produced by reproductive technology are stable

Haruo Hashimoto^*, Toshiro Arai, Yasuyuki Ohnishi, Tomoo Eto, Mamoru Ito, Kyoji Hioki, Ryo Suzuki, Toshimasa Yamauchi, Mitsuru Ohsugi, Muneo Saito, Yoshito Ueyama, Kazuyuki Tobe, Takashi Kadowaki, Norikazu Tamaoki, Kinori Kosaka

^*この論文の責任著者

内科学（第一）講座

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

6 被引用数 (Scopus)

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We studied the impact of "IVF-ET" on the glucose tolerance test (GTT), insulin tolerance test (ITT) and adiponectin to investigate differences in the phenotypes of B6J-lrs2^-/- mice. The B6J-lrs2^-/- mice (KO-Nat group) were prepared by natural mating. Other mice were produced by IVF-ET used ICR strain recipients and surrogate mothers (KO-IVF group). Measurement of body weight, GTT, ITT and blood sampling were performed at the ages of 6, 14 and 24 weeks after birth. Body weights, impaired glucose tolerance, insulin resistance and plasma adiponectin concentrations did not differ for each gender between the KO-IVF and KO-Nat groups. Therefore, we concluded that phenotypes of lrs2^-/- mice produced by reproductive technology are stable.

本文言語	英語
ページ（範囲）	149-154
ページ数	6
ジャーナル	Experimental Animals
巻	56
号	2
DOI	https://doi.org/10.1538/expanim.56.149
出版ステータス	出版済み - 2007/04/26

ASJC Scopus 主題領域

動物科学および動物学
生化学、遺伝学、分子生物学一般
獣医学一般

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10.1538/expanim.56.149

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title = "Phenotypes of IRS-2 deficient mice produced by reproductive technology are stable",

abstract = "We studied the impact of {"}IVF-ET{"} on the glucose tolerance test (GTT), insulin tolerance test (ITT) and adiponectin to investigate differences in the phenotypes of B6J-lrs2-/- mice. The B6J-lrs2-/- mice (KO-Nat group) were prepared by natural mating. Other mice were produced by IVF-ET used ICR strain recipients and surrogate mothers (KO-IVF group). Measurement of body weight, GTT, ITT and blood sampling were performed at the ages of 6, 14 and 24 weeks after birth. Body weights, impaired glucose tolerance, insulin resistance and plasma adiponectin concentrations did not differ for each gender between the KO-IVF and KO-Nat groups. Therefore, we concluded that phenotypes of lrs2-/- mice produced by reproductive technology are stable.",

keywords = "Adiponectin, Embryo transfer, IRS-2 deficient mice",

author = "Haruo Hashimoto and Toshiro Arai and Yasuyuki Ohnishi and Tomoo Eto and Mamoru Ito and Kyoji Hioki and Ryo Suzuki and Toshimasa Yamauchi and Mitsuru Ohsugi and Muneo Saito and Yoshito Ueyama and Kazuyuki Tobe and Takashi Kadowaki and Norikazu Tamaoki and Kinori Kosaka",

year = "2007",

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doi = "10.1538/expanim.56.149",

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T1 - Phenotypes of IRS-2 deficient mice produced by reproductive technology are stable

AU - Hashimoto, Haruo

AU - Arai, Toshiro

AU - Ohnishi, Yasuyuki

AU - Eto, Tomoo

AU - Ito, Mamoru

AU - Hioki, Kyoji

AU - Suzuki, Ryo

AU - Yamauchi, Toshimasa

AU - Ohsugi, Mitsuru

AU - Saito, Muneo

AU - Ueyama, Yoshito

AU - Tobe, Kazuyuki

AU - Kadowaki, Takashi

AU - Tamaoki, Norikazu

AU - Kosaka, Kinori

PY - 2007/4/26

Y1 - 2007/4/26

N2 - We studied the impact of "IVF-ET" on the glucose tolerance test (GTT), insulin tolerance test (ITT) and adiponectin to investigate differences in the phenotypes of B6J-lrs2-/- mice. The B6J-lrs2-/- mice (KO-Nat group) were prepared by natural mating. Other mice were produced by IVF-ET used ICR strain recipients and surrogate mothers (KO-IVF group). Measurement of body weight, GTT, ITT and blood sampling were performed at the ages of 6, 14 and 24 weeks after birth. Body weights, impaired glucose tolerance, insulin resistance and plasma adiponectin concentrations did not differ for each gender between the KO-IVF and KO-Nat groups. Therefore, we concluded that phenotypes of lrs2-/- mice produced by reproductive technology are stable.

AB - We studied the impact of "IVF-ET" on the glucose tolerance test (GTT), insulin tolerance test (ITT) and adiponectin to investigate differences in the phenotypes of B6J-lrs2-/- mice. The B6J-lrs2-/- mice (KO-Nat group) were prepared by natural mating. Other mice were produced by IVF-ET used ICR strain recipients and surrogate mothers (KO-IVF group). Measurement of body weight, GTT, ITT and blood sampling were performed at the ages of 6, 14 and 24 weeks after birth. Body weights, impaired glucose tolerance, insulin resistance and plasma adiponectin concentrations did not differ for each gender between the KO-IVF and KO-Nat groups. Therefore, we concluded that phenotypes of lrs2-/- mice produced by reproductive technology are stable.

KW - Adiponectin

KW - Embryo transfer

KW - IRS-2 deficient mice

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SN - 1341-1357

VL - 56

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JO - Experimental Animals

JF - Experimental Animals

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Phenotypes of IRS-2 deficient mice produced by reproductive technology are stable

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