Pharmacokinetics of brain natriuretic peptide in rats

Yukiva Hashimoto; Kazuwa Nakao; Norio Hama; Masashi Mukoyama; Hiroo Imura; Masato Yasuhara; Ryohei Hori

doi:10.1248/cpb.40.1650

Pharmacokinetics of brain natriuretic peptide in rats

Yukiva Hashimoto, Kazuwa Nakao, Norio Hama, Masashi Mukoyama, Hiroo Imura, Masato Yasuhara, Ryohei Hori

医薬品安全性学研究室

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

6 被引用数 (Scopus)

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The pharmacokinetics of rat brain natriuretic peptide (rBNP) was compared with that of a-rat atrial natriuretic peptide (a-rANP) in rats. After intravenous infusion in rats (600 pmol min^-1 kg'¹for 2 min), the disappearance of plasma rBNP was 4-fold slower than that of a-rANP. The estimated mean plasma clearance rates for rBNP and a-rANP were 45.9 ml min^kg*¹and 74.4 ml min'¹ kg'¹, respectively. The affinity of rBNP for the clearance receptor or degradation enzyme was considered to be lower than that of a-rANP.

本文言語	英語
ページ（範囲）	1650-1652
ページ数	3
ジャーナル	Chemical and Pharmaceutical Bulletin
巻	40
号	6
DOI	https://doi.org/10.1248/cpb.40.1650
出版ステータス	出版済み - 1992

ASJC Scopus 主題領域

化学一般
創薬

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10.1248/cpb.40.1650

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title = "Pharmacokinetics of brain natriuretic peptide in rats",

abstract = "The pharmacokinetics of rat brain natriuretic peptide (rBNP) was compared with that of a-rat atrial natriuretic peptide (a-rANP) in rats. After intravenous infusion in rats (600 pmol min-1 kg'1for 2 min), the disappearance of plasma rBNP was 4-fold slower than that of a-rANP. The estimated mean plasma clearance rates for rBNP and a-rANP were 45.9 ml min^kg*1and 74.4 ml min'1 kg'1, respectively. The affinity of rBNP for the clearance receptor or degradation enzyme was considered to be lower than that of a-rANP.",

keywords = "atrial natriuretic peptide, brain natriuretic peptide, clearance, pharmacokinetics",

author = "Yukiva Hashimoto and Kazuwa Nakao and Norio Hama and Masashi Mukoyama and Hiroo Imura and Masato Yasuhara and Ryohei Hori",

year = "1992",

doi = "10.1248/cpb.40.1650",

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T1 - Pharmacokinetics of brain natriuretic peptide in rats

AU - Hashimoto, Yukiva

AU - Nakao, Kazuwa

AU - Hama, Norio

AU - Mukoyama, Masashi

AU - Imura, Hiroo

AU - Yasuhara, Masato

AU - Hori, Ryohei

PY - 1992

Y1 - 1992

N2 - The pharmacokinetics of rat brain natriuretic peptide (rBNP) was compared with that of a-rat atrial natriuretic peptide (a-rANP) in rats. After intravenous infusion in rats (600 pmol min-1 kg'1for 2 min), the disappearance of plasma rBNP was 4-fold slower than that of a-rANP. The estimated mean plasma clearance rates for rBNP and a-rANP were 45.9 ml min^kg*1and 74.4 ml min'1 kg'1, respectively. The affinity of rBNP for the clearance receptor or degradation enzyme was considered to be lower than that of a-rANP.

AB - The pharmacokinetics of rat brain natriuretic peptide (rBNP) was compared with that of a-rat atrial natriuretic peptide (a-rANP) in rats. After intravenous infusion in rats (600 pmol min-1 kg'1for 2 min), the disappearance of plasma rBNP was 4-fold slower than that of a-rANP. The estimated mean plasma clearance rates for rBNP and a-rANP were 45.9 ml min^kg*1and 74.4 ml min'1 kg'1, respectively. The affinity of rBNP for the clearance receptor or degradation enzyme was considered to be lower than that of a-rANP.

KW - atrial natriuretic peptide

KW - brain natriuretic peptide

KW - clearance

KW - pharmacokinetics

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U2 - 10.1248/cpb.40.1650

DO - 10.1248/cpb.40.1650

M3 - 学術論文

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VL - 40

SP - 1650

EP - 1652

JO - Chemical and Pharmaceutical Bulletin

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Pharmacokinetics of brain natriuretic peptide in rats

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