Patisiran for advanced heart failure with hereditary transthyretin cardiac amyloidosis

Makiko Nakamura; Teruhiko Imamura; Koichiro Kinugawa

doi:10.1016/j.jccase.2021.01.007

Patisiran for advanced heart failure with hereditary transthyretin cardiac amyloidosis

Makiko Nakamura, Teruhiko Imamura^*, Koichiro Kinugawa

^*この論文の責任著者

内科学（第二）講座

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

2 被引用数 (Scopus)

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We experienced a 78-year-old woman who was diagnosed with hereditary transthyretin cardiac amyloidosis and administered patisiran for advanced heart failure refractory to tafamidis. The levels of N-terminal pro B-type natriuretic peptide and left ventricular mass index decreased following the six-month patisiran treatment without any complications. Patisiran might be a promising disease-modifying drug for hereditary transthyretin cardiac amyloidosis even in its advanced stage, although further evaluation in a large cohort is warranted.

本文言語	英語
ページ（範囲）	177-180
ページ数	4
ジャーナル	Journal of Cardiology Cases
巻	23
号	4
DOI	https://doi.org/10.1016/j.jccase.2021.01.007
出版ステータス	出版済み - 2021/04

ASJC Scopus 主題領域

循環器および心血管医学

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10.1016/j.jccase.2021.01.007

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abstract = "We experienced a 78-year-old woman who was diagnosed with hereditary transthyretin cardiac amyloidosis and administered patisiran for advanced heart failure refractory to tafamidis. The levels of N-terminal pro B-type natriuretic peptide and left ventricular mass index decreased following the six-month patisiran treatment without any complications. Patisiran might be a promising disease-modifying drug for hereditary transthyretin cardiac amyloidosis even in its advanced stage, although further evaluation in a large cohort is warranted.",

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author = "Makiko Nakamura and Teruhiko Imamura and Koichiro Kinugawa",

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doi = "10.1016/j.jccase.2021.01.007",

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AU - Imamura, Teruhiko

AU - Kinugawa, Koichiro

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N2 - We experienced a 78-year-old woman who was diagnosed with hereditary transthyretin cardiac amyloidosis and administered patisiran for advanced heart failure refractory to tafamidis. The levels of N-terminal pro B-type natriuretic peptide and left ventricular mass index decreased following the six-month patisiran treatment without any complications. Patisiran might be a promising disease-modifying drug for hereditary transthyretin cardiac amyloidosis even in its advanced stage, although further evaluation in a large cohort is warranted.

AB - We experienced a 78-year-old woman who was diagnosed with hereditary transthyretin cardiac amyloidosis and administered patisiran for advanced heart failure refractory to tafamidis. The levels of N-terminal pro B-type natriuretic peptide and left ventricular mass index decreased following the six-month patisiran treatment without any complications. Patisiran might be a promising disease-modifying drug for hereditary transthyretin cardiac amyloidosis even in its advanced stage, although further evaluation in a large cohort is warranted.

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Patisiran for advanced heart failure with hereditary transthyretin cardiac amyloidosis

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