New cerebrosides and ceramide with other constituents from the aerial parts of Raphidiocystis mannii Hook. f. and their cytotoxic activities

Yves M.Mba Nguekeu, Herman D.Sonfack Fozeng, Chika Ifeanyi Chukwuma, Saw Y.Yu Hnin, Nhat Nam Hoang, Emmanuel Mfotie Njoya, Silvère Augustin Ngouela, Mathieu Tene, Tshepiso Jan Makhafola, Hiroyuki Morita*, Maurice Ducret Awouafack

*この論文の責任著者

研究成果: ジャーナルへの寄稿コメント/討論

抄録

Two new cerebrosides, raphimanosides A (1) and B (2), and a new ceramide, raphimanide (3), were isolated from the aerial parts of Raphidiocystis mannii Hook. f., along with ten known compounds (4–13). Their structures were fully established, based on extensive analyses of 1H, 13C, DEPT, 2D NMR, ESIMS, and HRESIMS data and chemical conversion. Subsequently, methanol extract, ethyl acetate, and n-butanol soluble portions and the isolated compounds 1–9, 12, and 13 were assayed for their cytotoxic effects against three human cancer cell lines (MCF-7, HeLa and A549). None of the new compounds demonstrated efficacy against the tested cell lines. In contrast, the methanol extract, ethyl acetate soluble portion, and compounds 6, 7, 9, 12, and 13 showed moderate to low activities against different tested cell lines. Ethyl acetate soluble portion and compounds 13 and 7 were the most potent samples with the IC50 value of 41.25 μg/mL, 36.76 μM, and 13.16 μM against MCF-7, HeLa, and A549 cell lines, respectively. To the best of our knowledge, this is the inaugural investigation into the chemical constituents of the genus Raphidiocystis, offering novel insights into the chemotaxonomy of this hitherto poorly understood genus.

本文言語英語
論文番号e1700472
ページ(範囲)412-421
ページ数10
ジャーナルNatural Medicines
79
2
DOI
出版ステータス出版済み - 2025/03

ASJC Scopus 主題領域

  • 薬科学
  • 創薬
  • 補完代替医療
  • 有機化学

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