Neuromyelitis optica: Diagnosis and treatment

Yuji Nakatsuji*, Makoto Kinoshita, Tatsusada Okuno, Kazushiro Takata, Toru Koda, Josephe A. Honorat, Saburo Sakoda, Hideki Mochizuki

*この論文の責任著者

研究成果: 書籍の章/レポート/会議録査読

1 被引用数 (Scopus)

抄録

Neuromyelitis optica (NMO) is an inflammatory disorder of the central nervous system (CNS) characterized by optic neuritis and transverse myelitis. NMO is also known as Devic’s disease, after a case report by French neurologist Eugène Devic and his colleagues in the late nineteenth century. NMO has been considered a variant of multiple sclerosis (MS) and called opticospinal MS in Japan, where its prevalence is much higher than in Western countries. In 2004 however, an autoantibody, NMO-IgG (anti-aquaporin 4 antibody), was detected in the serum of patients with NMO, but not in patients with MS, indicating that NMO is independent of MS. Recent studies of NMO have contributed to a growing understanding of the disease that includes NMO spectrum disorders (NMOSD). In this chapter, we describe the clinical and laboratory characteristics of NMO/NMOSD and their treatments. While corticosteroids and/or plasmapheresis are treatments for NMO/NMOSD, novel therapeutic approaches are being developed through research elucidating the pathomechanisms of NMO.

本文言語英語
ホスト出版物のタイトルNeuroimmunological Diseases
出版社Springer Japan
ページ135-152
ページ数18
ISBN(電子版)9784431555940
ISBN(印刷版)9784431555933
DOI
出版ステータス出版済み - 2016/01/01

ASJC Scopus 主題領域

  • 医学一般
  • 免疫学および微生物学一般
  • 神経科学一般

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