抄録
Neuromyelitis optica (NMO) is an inflammatory disorder of the central nervous system (CNS) characterized by optic neuritis and transverse myelitis. NMO is also known as Devic’s disease, after a case report by French neurologist Eugène Devic and his colleagues in the late nineteenth century. NMO has been considered a variant of multiple sclerosis (MS) and called opticospinal MS in Japan, where its prevalence is much higher than in Western countries. In 2004 however, an autoantibody, NMO-IgG (anti-aquaporin 4 antibody), was detected in the serum of patients with NMO, but not in patients with MS, indicating that NMO is independent of MS. Recent studies of NMO have contributed to a growing understanding of the disease that includes NMO spectrum disorders (NMOSD). In this chapter, we describe the clinical and laboratory characteristics of NMO/NMOSD and their treatments. While corticosteroids and/or plasmapheresis are treatments for NMO/NMOSD, novel therapeutic approaches are being developed through research elucidating the pathomechanisms of NMO.
本文言語 | 英語 |
---|---|
ホスト出版物のタイトル | Neuroimmunological Diseases |
出版社 | Springer Japan |
ページ | 135-152 |
ページ数 | 18 |
ISBN(電子版) | 9784431555940 |
ISBN(印刷版) | 9784431555933 |
DOI | |
出版ステータス | 出版済み - 2016/01/01 |
ASJC Scopus 主題領域
- 医学一般
- 免疫学および微生物学一般
- 神経科学一般