TY - JOUR
T1 - Neurodevelopmental outcomes at 3 years for infants with congenital heart disease and very-low birthweight
AU - Yoshida, Taketoshi
AU - Hiraiwa, Akiko
AU - Ibuki, Keijiro
AU - Makimoto, Masami
AU - Inomata, Satomi
AU - Tamura, Kentaro
AU - Kawasaki, Yukako
AU - Ozawa, Sayaka
AU - Hirono, Keiichi
AU - Ichida, Fukiko
N1 - Publisher Copyright:
© 2020 Japan Pediatric Society
PY - 2020/7/1
Y1 - 2020/7/1
N2 - Background: Both congenital heart disease (CHD) and very-low birthweight (VLBW) infants are at a very high risk of neurodevelopmental delay. We investigated neurological development at 3 years in pediatric patients with CHD after surgical intervention, those of VLBW, and healthy controls. Methods: We enrolled pediatric patients with CHD (n = 67), VLBW (n = 67), and healthy controls (n = 81). Infants with CHD were grouped into those with single ventricle and two ventricles, and infants with VLBW were grouped into those with birthweights of <1000 and 1000–1499 g. Neurodevelopmental outcomes at 3 years were evaluated using the Bayley Scales of Infant and Toddler Development, Third Edition. Results: Compared with healthy controls, a significant deficit in the language, cognition, and motor skills scores were observed in infants with CHD and VLBW. Infants with a single ventricle exhibited significantly low scores in language and gross motor skills. No statistically significant difference was observed between the birthweight groups of <1000 and 1000–1499 g. Conclusion: Neurodevelopmental outcomes for infants with both CHD and VLBW showed impairment. Notably, neurodevelopmental delays in infants with a single ventricle were remarkable. Thus, because infants with both CHD and VLBW are at high risk of neurodevelopmental disorders, periodic developmental screenings and support are warranted for these children.
AB - Background: Both congenital heart disease (CHD) and very-low birthweight (VLBW) infants are at a very high risk of neurodevelopmental delay. We investigated neurological development at 3 years in pediatric patients with CHD after surgical intervention, those of VLBW, and healthy controls. Methods: We enrolled pediatric patients with CHD (n = 67), VLBW (n = 67), and healthy controls (n = 81). Infants with CHD were grouped into those with single ventricle and two ventricles, and infants with VLBW were grouped into those with birthweights of <1000 and 1000–1499 g. Neurodevelopmental outcomes at 3 years were evaluated using the Bayley Scales of Infant and Toddler Development, Third Edition. Results: Compared with healthy controls, a significant deficit in the language, cognition, and motor skills scores were observed in infants with CHD and VLBW. Infants with a single ventricle exhibited significantly low scores in language and gross motor skills. No statistically significant difference was observed between the birthweight groups of <1000 and 1000–1499 g. Conclusion: Neurodevelopmental outcomes for infants with both CHD and VLBW showed impairment. Notably, neurodevelopmental delays in infants with a single ventricle were remarkable. Thus, because infants with both CHD and VLBW are at high risk of neurodevelopmental disorders, periodic developmental screenings and support are warranted for these children.
KW - Bayley Scales
KW - congenital heart disease
KW - neurodevelopmental outcomes
KW - very-low-birthweight infant
UR - http://www.scopus.com/inward/record.url?scp=85087220893&partnerID=8YFLogxK
U2 - 10.1111/ped.14160
DO - 10.1111/ped.14160
M3 - 学術論文
C2 - 31957091
AN - SCOPUS:85087220893
SN - 1328-8067
VL - 62
SP - 797
EP - 803
JO - Pediatrics International
JF - Pediatrics International
IS - 7
ER -