TY - JOUR
T1 - Nature's TRAIL - On a path to cancer immunotherapy
AU - Smyth, Mark J.
AU - Takeda, Kazuyoshi
AU - Hayakawa, Yoshihiro
AU - Peschon, Jacques J.
AU - Van Den Brink, Marcel R.M.
AU - Yagita, Hideo
N1 - Funding Information:
The authors acknowledge the support of The Human Frontier Science Program, grants HL69929 and HL72412 from the National Institutes of Health, and the National Health and Medical Research Council of Australia.
PY - 2003/1/1
Y1 - 2003/1/1
N2 - The TNF-related apoptosis-inducing ligand (TRAIL) offers great promise as a cancer therapeutic. Initially, soluble recombinant versions of the TRAIL molecule have exhibited specific tumoricidal activity against a variety of tumors alone, or in combination with other cancer treatments, and much anticipation awaits the outcomes from early clinical trials. More recently, the natural role of TRAIL has been explored in tumor and allogeneic bone marrow transplantation models in the mouse. Strikingly, the TRAIL effector pathway appears a vital component of immunosurveillance of spontaneous or resident tumor cells by both T cells and NK cells, stimulating more hope that manipulating TRAIL activity is a natural path to improved cancer immunotherapy.
AB - The TNF-related apoptosis-inducing ligand (TRAIL) offers great promise as a cancer therapeutic. Initially, soluble recombinant versions of the TRAIL molecule have exhibited specific tumoricidal activity against a variety of tumors alone, or in combination with other cancer treatments, and much anticipation awaits the outcomes from early clinical trials. More recently, the natural role of TRAIL has been explored in tumor and allogeneic bone marrow transplantation models in the mouse. Strikingly, the TRAIL effector pathway appears a vital component of immunosurveillance of spontaneous or resident tumor cells by both T cells and NK cells, stimulating more hope that manipulating TRAIL activity is a natural path to improved cancer immunotherapy.
UR - http://www.scopus.com/inward/record.url?scp=0037240850&partnerID=8YFLogxK
U2 - 10.1016/S1074-7613(02)00502-2
DO - 10.1016/S1074-7613(02)00502-2
M3 - 簡易調査
C2 - 12530970
AN - SCOPUS:0037240850
SN - 1074-7613
VL - 18
SP - 1
EP - 6
JO - Immunity
JF - Immunity
IS - 1
ER -