TY - JOUR
T1 - Morbidity and mortality in antiphospholipid syndrome based on cluster analysis
T2 - A 10-year longitudinal cohort study
AU - Ogata, Yusuke
AU - Fujieda, Yuichiro
AU - Sugawara, Masanari
AU - Sato, Taiki
AU - Ohnishi, Naoki
AU - Kono, Michihito
AU - Kato, Masaru
AU - Oku, Kenji
AU - Amengual, Olga
AU - Atsumi, Tatsuya
N1 - Publisher Copyright:
© 2020 The Author(s). Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved.
PY - 2021/3/1
Y1 - 2021/3/1
N2 - Objective: Using cluster analysis, to identify the subgroup of patients with APS with the poorest prognosis and clarify the characteristics of that subgroup. Methods: This is a longitudinal retrospective cohort study of APS patients. Using clinical data and the profile of aPL, cluster analysis was performed to classify the patients into subgroups. Events were defined as thrombosis, severe bleeding, and mortality. Results: A total of 168 patients with APS were included. Cluster analysis classified the patients into three subgroups; Cluster A (n = 61): Secondary APS, Cluster B (n = 56): Accumulation of cardiovascular risks and arterial thrombosis, Cluster C (n = 61): Triple positivity of aPL and venous thrombosis. Cluster B showed significantly higher frequency of the events and higher mortality compared with the other clusters (P = 0.0112 for B vs A and P = 0.0471 for B vs C). Conclusion: Using cluster analysis, we clarified the characteristics of the APS patients with the poorest prognosis. Risk factors for cardiovascular disease may further increase events in patients with APS.
AB - Objective: Using cluster analysis, to identify the subgroup of patients with APS with the poorest prognosis and clarify the characteristics of that subgroup. Methods: This is a longitudinal retrospective cohort study of APS patients. Using clinical data and the profile of aPL, cluster analysis was performed to classify the patients into subgroups. Events were defined as thrombosis, severe bleeding, and mortality. Results: A total of 168 patients with APS were included. Cluster analysis classified the patients into three subgroups; Cluster A (n = 61): Secondary APS, Cluster B (n = 56): Accumulation of cardiovascular risks and arterial thrombosis, Cluster C (n = 61): Triple positivity of aPL and venous thrombosis. Cluster B showed significantly higher frequency of the events and higher mortality compared with the other clusters (P = 0.0112 for B vs A and P = 0.0471 for B vs C). Conclusion: Using cluster analysis, we clarified the characteristics of the APS patients with the poorest prognosis. Risk factors for cardiovascular disease may further increase events in patients with APS.
KW - antiphospholipid syndrome (APS)
KW - cardiovascular risks
KW - cluster analysis
KW - history of arterial thrombosis
KW - morbidity
KW - mortality
UR - http://www.scopus.com/inward/record.url?scp=85099255965&partnerID=8YFLogxK
U2 - 10.1093/rheumatology/keaa542
DO - 10.1093/rheumatology/keaa542
M3 - 学術論文
C2 - 32944779
AN - SCOPUS:85099255965
SN - 1462-0324
VL - 60
SP - 1331
EP - 1337
JO - Rheumatology (United Kingdom)
JF - Rheumatology (United Kingdom)
IS - 3
ER -
