@article{f77adbde298a49d8bb899431ea3a88df,
title = "Midline brain abnormalities in established bipolar affective disorder",
abstract = "Background: Morphologic changes of cortico-limbic regions have been reported in bipolar disorder, but it remains unclear whether midline brain abnormalities relevant to cortico-limbic connectivity are also present. Methods: We used magnetic resonance imaging to investigate the size of the adhesio interthalamica (AI) and cavum septi pellucidi (CSP), as well as third ventricular volume, in 26 patients with bipolar I disorder and 24 matched controls. Results: CSP length and prevalence of a large CSP did not differ between the groups, but bipolar patients had significantly shorter AI and larger third ventricles compared to controls. Limitations: A comprehensive investigation of medication effects was not possible due to incomplete medication data. Conclusions: These findings implicate a role for the AI and connected brain regions in the neurobiology of bipolar disorder.",
keywords = "Adhesio interthalamica, Bipolar disorder, Cavum septi pellucidi, Magnetic resonance imaging, Third ventricle",
author = "Tsutomu Takahashi and Malhi, {Gin S.} and Wood, {Stephen J.} and Murat Y{\"u}cel and Mark Walterfang and Kazue Nakamura and Michio Suzuki and Christos Pantelis",
note = "Funding Information: This study was supported in part by a Grants-in-Aid for Scientific Research (No. 19591346 ) from the Japanese Society for the Promotion of Science , and a Research Grant ( 17-2,18-6 ) for Nervous and Mental Disorders from the Ministry of Health and Welfare , Japan. A/Prof. Wood is currently supported by an NHMRC Clinical Career Developmental Award and a NARSAD Young Investigator Award. A/Prof. Y{\"u}cel is supported by NHMRC Clinical Career Development Grant 509345 . Dr. Walterfang was supported by a Pfizer Neuroscience Research Grant. Prof. Malhi is supported by an NHMRC Program Grant. None of the funding sources had any role in the study design; in the collection, analysis and interpretation of data; in the writing of the report; and in the decision to submit the paper for publication. ",
year = "2010",
month = may,
doi = "10.1016/j.jad.2009.09.003",
language = "英語",
volume = "122",
pages = "301--305",
journal = "Journal of Affective Disorders",
issn = "0165-0327",
publisher = "Elsevier B.V.",
number = "3",
}
