Membrane fatty acid levels as a predictor of treatment response in chronic schizophrenia

Tomiki Sumiyoshi*, Yuko Higuchi, Mie Matsui, Hiroko Itoh, Takashi Uehara, Toru Itoh, Hirofumi Arai, Chieko Takamiya, Michio Suzuki, Masayoshi Kurachi

*この論文の責任著者

研究成果: ジャーナルへの寄稿学術論文査読

31 被引用数 (Scopus)

抄録

Abnormal fatty acid composition in neural membranes, that is, the balance between essential polyunsaturated fatty acids (EPUFAs) and saturated fatty acids, has been suggested to be related to the psychotic symptoms and cognitive impairment of schizophrenia. This study was conducted to test the hypothesis that the ability of atypical antipsychotic drugs to ameliorate positive symptoms and cognitive function relevant to daily living would be predicted by baseline EPUFAs concentrations in the erythrocyte membrane in subjects with schizophrenia. A total of 24 actively psychotic patients with schizophrenia participated in the study. After blood drawing, they were treated with olanzapine or perospirone. The Scale for the Assessment of Positive Symptoms (SAPS) and the Scale for Assessment of Negative symptoms (SANS), as well as the script tasks, a measure of event schema recognition, were administered at baseline and 3 months after the start of treatment. Erythrocyte membrane fatty acid levels were analysed using a gas chromatography system. Scores of SAPS and SANS, as well as script task performance, were improved during treatment with either antipsychotic drug. Regression analysis indicates baseline EPUFAs concentrations were positively and negatively related with percent improvement of positive symptoms and script task performance, respectively. The results of this study suggest composition of phospholipids in the erythrocyte membrane provide a feasible marker to predict treatment response in patients with schizophrenia.

本文言語英語
ページ(範囲)23-27
ページ数5
ジャーナルPsychiatry research
186
1
DOI
出版ステータス出版済み - 2011/03/30

ASJC Scopus 主題領域

  • 精神医学および精神衛生
  • 生物学的精神医学

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