Measurement of the human esophageal cancer in an early stage with Raman spectroscopy

Yasuhiro Maeda, Mika Ishigaki, Akinori Taketani, Bibin B. Andriana, Ryu Ishihara, Hidetoshi Sato

研究成果: 書籍の章/レポート/会議録会議への寄与査読

5 被引用数 (Scopus)

抄録

The esophageal cancer has a tendency to transfer to another part of the body and the surgical operation itself sometimes gives high risk in vital function because many delicate organs exist near the esophagus. So the esophageal cancer is a disease with a high mortality. So, in order to lead a higher survival rate five years after the cancers treatment, the investigation of the diagnosis methods or techniques of the cancer in an early stage and support the therapy are required. In this study, we performed the ex vivo experiments to obtain the Raman spectra from normal and early-stage tumor (stage-0) human esophageal sample by using Raman spectroscopy. The Raman spectra are collected by the homemade Raman spectrometer with the wavelength of 785 nm and Raman probe with 600-um-diameter. The principal component analysis (PCA) is performed after collection of spectra to recognize which materials changed in normal part and cancerous pert. After that, the linear discriminant analysis (LDA) is performed to predict the tissue type. The result of PCA indicates that the tumor tissue is associated with a decrease in tryptophan concentration. Furthermore, we can predict the tissue type with 80% accuracy by LDA which model is made by tryptophan bands.

本文言語英語
ホスト出版物のタイトルOptical Diagnostics and Sensing XIV
ホスト出版物のサブタイトルToward Point-of-Care Diagnostics
出版社SPIE
ISBN(印刷版)9780819498649
DOI
出版ステータス出版済み - 2014
イベントOptical Diagnostics and Sensing XIV: Toward Point-of-Care Diagnostics - San Francisco, CA, 米国
継続期間: 2014/02/032014/02/06

出版物シリーズ

名前Progress in Biomedical Optics and Imaging - Proceedings of SPIE
8951
ISSN(印刷版)1605-7422

学会

学会Optical Diagnostics and Sensing XIV: Toward Point-of-Care Diagnostics
国/地域米国
CitySan Francisco, CA
Period2014/02/032014/02/06

ASJC Scopus 主題領域

  • 電子材料、光学材料、および磁性材料
  • 原子分子物理学および光学
  • 生体材料
  • 放射線学、核医学およびイメージング

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