Macrophage migration inhibitory factor: A mediator of matrix metalloproteinase production

Tadamichi Shimizu*

*この論文の責任著者

研究成果: 書籍の章/レポート/会議録査読

抄録

Macrophage migration inhibitory factor (MIF) is a cytokine that induces the production of a large number of proinflammatory molecules and pituitary-derived hormone, which potentiate endotoxemia. MIF has been reported to be primarily expressed in T cells and macrophages. However, recent studies have revealed this protein to be ubiquitously expressed in various cell types, and have indicated that it has more far-reaching non-immunological role(s) in a variety of pathological states. Of note, it has become evident that MIF has a broad activity on glucocorticoid-induced immunomodulation, D-dopachrometautomerase activity, and the induction of matrix metalloproteinases (MMPs). MIF plays an important role in the pathogenesis of injury, such as ultraviolet (UV)-induced damage and rheumatoid arthritis (RA). UV irradiation up-regulates the production of inflammatory cytokines, and the UV-induced increase in MMPs in dermal fibroblasts is mediated in part by MIF and IL-1β. Furthermore, MMPs are involved in tissue remodeling and may be critical to cartilage formation in RA. It is also known that MIF up-regulates the expression of MMPs 1 and 3 in the fibroblasts-like synoviocytes of patients with RA. Therefore, MIF antagonism could be a very attractive therapeutic pathway to decrease the effects of injury and RA. This chapter reviews the latest findings on the roles of MIF with regard to injury and RA.

本文言語英語
ホスト出版物のタイトルMatrix Metalloproteinases
ホスト出版物のサブタイトルBiology, Functions and Clinical Implications
出版社Nova Science Publishers, Inc.
ページ189-202
ページ数14
ISBN(印刷版)9781621007890
出版ステータス出版済み - 2012

ASJC Scopus 主題領域

  • 生化学、遺伝学、分子生物学一般

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