Long-term treatment with Hachimi-jio-gan attenuates kidney damage in spontaneously diabetic WBN/Kob rats

Takako Nakagawa, Takako Yokozawa*, Noriko Yamabe, Dong Young Rhyn, Hirozo Goto, Yutaka Shimada, Naotoshi Shibahara

*この論文の責任著者

研究成果: ジャーナルへの寄稿学術論文査読

21 被引用数 (Scopus)

抄録

Diabetes mellitus is now the most common cause of end-stage renal failure. In this study, the effects of Hachimi-jio-gan on diabetic kidney damage in spontaneously diabetic WBN/Kob rats were examined. Oral administration of Hachimi-jio-gan to WBN/Kob rats for 25 weeks significantly suppressed urinary protein excretion. It did not affect-body weight loss or blood glucose levels, whereas it reversed the increase in kidney weight of WBN/Kob rats. Hachimi-jio-gan also reduced fibronectin and transforming growth factor β1 (TGF-β1) protein expression in the renal cortex. Furthermore, renal lipid peroxidation levels of WBN/Kob rats given Hachimi-jio-gan were significantly lower than those of untreated controls. Renal superoxide dismutase activity was elevated by Hachimi-jio-gan treatment in a dose-dependent manner. These results suggested that Hachimi-jio-gan could prevent diabetic kidney damage by reducing renal oxidative injury and expression of fibronectin and TGF-β1 proteins, which are all involved in the pathophysiology of diabetic nephropathy.

本文言語英語
ページ(範囲)1205-1212
ページ数8
ジャーナルJournal of Pharmacy and Pharmacology
57
9
DOI
出版ステータス出版済み - 2005/09

ASJC Scopus 主題領域

  • 薬理学
  • 薬科学

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