抄録
Lesions of atherosclerosis occur in the innermost layer of the artery wall and consist primarily of proliferated smooth muscle cells surrounded by large amounts of connective tissue, numerous lipid-laden macrophages, and varying numbers of lymphocytes. Growth-regulatory molecules may be involved in intimal accumulation and proliferation of smooth muscle cells responsible for the occlusive lesions of atherosclerosis. Platelet-derived growth factor (PDGF) B-chain protein was found within macrophages in all stages of lesion development in both human and nonhuman primate atherosclerosis. Thus macrophages may play a critical role in the disease by providing PDGF, a potent chemotactic and growth-stimulatory molecule, to the intimal smooth muscle cells.
本文言語 | 英語 |
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ページ(範囲) | 1009-1012 |
ページ数 | 4 |
ジャーナル | Science |
巻 | 248 |
号 | 4958 |
DOI | |
出版ステータス | 出版済み - 1990 |
ASJC Scopus 主題領域
- 一般