Localization of PDGF-B protein in macrophages in all phases of atherogenesis

Russell Ross*, Junichi Masuda, Elaine W. Raines, Allen M. Gown, Shogo Katsuda, Masakiyo Sasahara, L. Trevor Malden, Hideyuki Masuko, Hiroshi Sato

*この論文の責任著者

研究成果: ジャーナルへの寄稿学術論文査読

522 被引用数 (Scopus)

抄録

Lesions of atherosclerosis occur in the innermost layer of the artery wall and consist primarily of proliferated smooth muscle cells surrounded by large amounts of connective tissue, numerous lipid-laden macrophages, and varying numbers of lymphocytes. Growth-regulatory molecules may be involved in intimal accumulation and proliferation of smooth muscle cells responsible for the occlusive lesions of atherosclerosis. Platelet-derived growth factor (PDGF) B-chain protein was found within macrophages in all stages of lesion development in both human and nonhuman primate atherosclerosis. Thus macrophages may play a critical role in the disease by providing PDGF, a potent chemotactic and growth-stimulatory molecule, to the intimal smooth muscle cells.

本文言語英語
ページ(範囲)1009-1012
ページ数4
ジャーナルScience
248
4958
DOI
出版ステータス出版済み - 1990

ASJC Scopus 主題領域

  • 一般

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