@article{753b1aa3e92f475da83c7ea6a0d1eb72,
title = "L-DOPA neurotoxicity is mediated by glutamate release in cultured rat striatal neurons",
abstract = "The exposure of cultured rat striatal neurons to L-DOPA caused marked cell death. The L-DOPA cytotoxicity was inhibited by the addition of Mg2+ to and by the removal of Ca2+ from the culture medium, and also by the application of tetrodotoxin. Moreover, prolonged application of L-DOPA increased the glutamate content in the culture medium. These results indicate that L-DOPA produces neurotoxicity by facilitating glutamate release.",
keywords = "Culture, Glutamate, L-DOPA, Neuroprotection, Neurotoxicity, Release, Striatum",
author = "Takehiko Maeda and Cheng, {Neng Neng} and Toshiaki Kume and Satoshi Kaneko and Hanae Kouchiyama and Akinori Akaike and Mutsuaki Ueda and Masamichi Satoh and Yoshio Goshima and Yoshimi Misu",
note = "Funding Information: This study was supported in part by Grants-in-Aid for Scientific Research (07457539 and 07557328) and on priority areas (07264221) from the Ministry of Education, Science and Culture, Japan.",
year = "1997",
month = oct,
day = "10",
doi = "10.1016/S0006-8993(97)00908-6",
language = "英語",
volume = "771",
pages = "159--162",
journal = "Brain Research",
issn = "0006-8993",
publisher = "Elsevier B.V.",
number = "1",
}