Isolation of alkamides with death receptor-enhancing activities from Piper Chaba

Hoque Tahmina; Kazufumi Toume; Midori A. Arai; Samir K. Sadhu; Firoj Ahmed; Masami Ishibashi

doi:10.3987/COM-14-S(K)68

Isolation of alkamides with death receptor-enhancing activities from Piper Chaba

Hoque Tahmina, Kazufumi Toume, Midori A. Arai, Samir K. Sadhu, Firoj Ahmed, Masami Ishibashi^*

^*この論文の責任著者

和漢医薬学総合研究所薬用資源管理部門

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

2 被引用数 (Scopus)

抄録

In the screening program for natural bioactive compounds that enhance the expression of death receptor 5 (DR5), activity-guided fractionation ofthe Piper chaba (Piperaceae) root MeOH extract led to the isolation of four alkamides (1-4). Compounds 1, 3, and 4 enhanced DR5 promoter activity while pellitorine (3) exhibited TRAIL-resistance-overcoming activity.

本文言語	英語
ページ（範囲）	1317-1322
ページ数	6
ジャーナル	Heterocycles
巻	90
号	2
DOI	https://doi.org/10.3987/COM-14-S(K)68
出版ステータス	出版済み - 2015

ASJC Scopus 主題領域

分析化学
薬理学
有機化学

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10.3987/COM-14-S(K)68

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title = "Isolation of alkamides with death receptor-enhancing activities from Piper Chaba",

abstract = "In the screening program for natural bioactive compounds that enhance the expression of death receptor 5 (DR5), activity-guided fractionation ofthe Piper chaba (Piperaceae) root MeOH extract led to the isolation of four alkamides (1-4). Compounds 1, 3, and 4 enhanced DR5 promoter activity while pellitorine (3) exhibited TRAIL-resistance-overcoming activity.",

author = "Hoque Tahmina and Kazufumi Toume and Arai, {Midori A.} and Sadhu, {Samir K.} and Firoj Ahmed and Masami Ishibashi",

note = "Publisher Copyright: {\textcopyright} 2015 The Japan Institute of Heterocyclic Chemistry.",

year = "2015",

doi = "10.3987/COM-14-S(K)68",

language = "英語",

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AU - Tahmina, Hoque

AU - Toume, Kazufumi

AU - Arai, Midori A.

AU - Sadhu, Samir K.

AU - Ahmed, Firoj

AU - Ishibashi, Masami

PY - 2015

Y1 - 2015

N2 - In the screening program for natural bioactive compounds that enhance the expression of death receptor 5 (DR5), activity-guided fractionation ofthe Piper chaba (Piperaceae) root MeOH extract led to the isolation of four alkamides (1-4). Compounds 1, 3, and 4 enhanced DR5 promoter activity while pellitorine (3) exhibited TRAIL-resistance-overcoming activity.

AB - In the screening program for natural bioactive compounds that enhance the expression of death receptor 5 (DR5), activity-guided fractionation ofthe Piper chaba (Piperaceae) root MeOH extract led to the isolation of four alkamides (1-4). Compounds 1, 3, and 4 enhanced DR5 promoter activity while pellitorine (3) exhibited TRAIL-resistance-overcoming activity.

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U2 - 10.3987/COM-14-S(K)68

DO - 10.3987/COM-14-S(K)68

M3 - 学術論文

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SN - 0385-5414

VL - 90

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JO - Heterocycles

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Isolation of alkamides with death receptor-enhancing activities from Piper Chaba

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