Ionizing radiation suppresses FAP-1 mRNA level in A549 cells via p53 activation

Toru Yamada; Muneharu Maruyama; Tadashi Fujita; Koutarou Miyabayashi; Chie Shinoda; Yukio Kawagishi; Takashi Fujishita; Ryuji Hayashi; Toshiro Miwa; Nobuki Arai; Shoko Matsui; Eiji Sugiyama; Masashi Kobayashi

doi:10.1016/j.febslet.2006.07.003

Ionizing radiation suppresses FAP-1 mRNA level in A549 cells via p53 activation

Toru Yamada, Muneharu Maruyama^*, Tadashi Fujita, Koutarou Miyabayashi, Chie Shinoda, Yukio Kawagishi, Takashi Fujishita, Ryuji Hayashi, Toshiro Miwa, Nobuki Arai, Shoko Matsui, Eiji Sugiyama, Masashi Kobayashi

^*この論文の責任著者

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

4 被引用数 (Scopus)

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Ionizing radiation (IR) is known to upregulate cell surface Fas through p53 activation in various cells. However, the signaling pathway intermediating between p53 activation and cell surface Fas upregulation remains to be elucidated. Recently, Fas-associated phosphatase-1 (FAP-1) has been reported to associate with Fas and inhibit cell surface Fas expression. We evaluated the expression of FAP-1 mRNA following IR in A549 cells. Ionizing radiation inhibited the expression of FAP-1 mRNA. Pretreatment with p53 inhibitor pifithrin α cancelled the IR-induced downregulation of FAP-1 mRNA. These results suggest that IR-induced p53 activation may upregulate cell surface Fas via the down-modulation of FAP-1.

本文言語	英語
ページ（範囲）	4387-4391
ページ数	5
ジャーナル	FEBS Letters
巻	580
号	18
DOI	https://doi.org/10.1016/j.febslet.2006.07.003
出版ステータス	出版済み - 2006/08/07

ASJC Scopus 主題領域

生物理学
構造生物学
生化学
分子生物学
遺伝学
細胞生物学

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10.1016/j.febslet.2006.07.003

引用スタイル

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title = "Ionizing radiation suppresses FAP-1 mRNA level in A549 cells via p53 activation",

abstract = "Ionizing radiation (IR) is known to upregulate cell surface Fas through p53 activation in various cells. However, the signaling pathway intermediating between p53 activation and cell surface Fas upregulation remains to be elucidated. Recently, Fas-associated phosphatase-1 (FAP-1) has been reported to associate with Fas and inhibit cell surface Fas expression. We evaluated the expression of FAP-1 mRNA following IR in A549 cells. Ionizing radiation inhibited the expression of FAP-1 mRNA. Pretreatment with p53 inhibitor pifithrin α cancelled the IR-induced downregulation of FAP-1 mRNA. These results suggest that IR-induced p53 activation may upregulate cell surface Fas via the down-modulation of FAP-1.",

keywords = "Fas, Fas-associated phosphatase-1, Ionizing radiation, p53",

author = "Toru Yamada and Muneharu Maruyama and Tadashi Fujita and Koutarou Miyabayashi and Chie Shinoda and Yukio Kawagishi and Takashi Fujishita and Ryuji Hayashi and Toshiro Miwa and Nobuki Arai and Shoko Matsui and Eiji Sugiyama and Masashi Kobayashi",

year = "2006",

month = aug,

day = "7",

doi = "10.1016/j.febslet.2006.07.003",

language = "英語",

volume = "580",

pages = "4387--4391",

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T1 - Ionizing radiation suppresses FAP-1 mRNA level in A549 cells via p53 activation

AU - Yamada, Toru

AU - Maruyama, Muneharu

AU - Fujita, Tadashi

AU - Miyabayashi, Koutarou

AU - Shinoda, Chie

AU - Kawagishi, Yukio

AU - Fujishita, Takashi

AU - Hayashi, Ryuji

AU - Miwa, Toshiro

AU - Arai, Nobuki

AU - Matsui, Shoko

AU - Sugiyama, Eiji

AU - Kobayashi, Masashi

PY - 2006/8/7

Y1 - 2006/8/7

N2 - Ionizing radiation (IR) is known to upregulate cell surface Fas through p53 activation in various cells. However, the signaling pathway intermediating between p53 activation and cell surface Fas upregulation remains to be elucidated. Recently, Fas-associated phosphatase-1 (FAP-1) has been reported to associate with Fas and inhibit cell surface Fas expression. We evaluated the expression of FAP-1 mRNA following IR in A549 cells. Ionizing radiation inhibited the expression of FAP-1 mRNA. Pretreatment with p53 inhibitor pifithrin α cancelled the IR-induced downregulation of FAP-1 mRNA. These results suggest that IR-induced p53 activation may upregulate cell surface Fas via the down-modulation of FAP-1.

AB - Ionizing radiation (IR) is known to upregulate cell surface Fas through p53 activation in various cells. However, the signaling pathway intermediating between p53 activation and cell surface Fas upregulation remains to be elucidated. Recently, Fas-associated phosphatase-1 (FAP-1) has been reported to associate with Fas and inhibit cell surface Fas expression. We evaluated the expression of FAP-1 mRNA following IR in A549 cells. Ionizing radiation inhibited the expression of FAP-1 mRNA. Pretreatment with p53 inhibitor pifithrin α cancelled the IR-induced downregulation of FAP-1 mRNA. These results suggest that IR-induced p53 activation may upregulate cell surface Fas via the down-modulation of FAP-1.

KW - Fas

KW - Fas-associated phosphatase-1

KW - Ionizing radiation

KW - p53

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U2 - 10.1016/j.febslet.2006.07.003

DO - 10.1016/j.febslet.2006.07.003

M3 - 学術論文

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AN - SCOPUS:33746336984

SN - 0014-5793

VL - 580

SP - 4387

EP - 4391

JO - FEBS Letters

JF - FEBS Letters

IS - 18

ER -

Ionizing radiation suppresses FAP-1 mRNA level in A549 cells via p53 activation

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