抄録
IL-2 production by PHA-stimulated human lymphocytes in umbilical blood was studied ontogenetically. Lymphocytes from the 16-week-old fetus produced appreciable amounts of interleukin-2 (IL-2). In 16- to 36-week-old fetuses the IL-2 production rate was found to be significantly higher than that in adults. When signal transduction, which is mediated by high affinity IL-2 receptors (IL-2R), was studied after adding exogenous IL-2 to PHA-blast lymphocytes, the response of the 24-week-old fetus was similar to that of adults. These results indicate that the attainment of IL-2 production and the function of IL-2 receptors are completed at a relatively early stage of fetal development.
| 本文言語 | 英語 |
|---|---|
| ページ（範囲） | 247-255 |
| ページ数 | 9 |
| ジャーナル | Journal of Reproductive Immunology |
| 巻 | 14 |
| 号 | 3 |
| DOI | |
| 出版ステータス | 出版済み - 1988/12 |
ASJC Scopus 主題領域
- 免疫アレルギー学
- 免疫学
- 生殖医学
- 産婦人科学