TY - JOUR
T1 - Inhibitory effects of Cordia spinescens extracts and their constituents on reverse transcriptase and protease from human immunodeficiency virus
AU - Lim, Yasmina Aura
AU - Kojima, Shiho
AU - Nakamura, Norio
AU - Miyashiro, Hirotsugu
AU - Fushimi, Hirotoshi
AU - Komatsu, Katsuko
AU - Hattori, Masao
AU - Shimotohno, Kunitada
AU - Gupta, Mahabir P.
AU - Correa, Mireya
PY - 1997/11
Y1 - 1997/11
N2 - By bioactive-guided fractionation of a water extract of Cordia spinescens, magnesium lithospermate (1), calcium rosmarinate (2) and magnesium rosmarinate (3) were isolated as potent inhibitory substances against HIV-1 reverse transcriptase (RT) with IC50 values of 0.8, 5.8 and 3.1 μM, respectively. However, they were weak HIV-1 protease (PR) inhibitors with IC50 >100 μM. The RT inhibition by these compounds was noncompetitive with respect to dTTP substrate.
AB - By bioactive-guided fractionation of a water extract of Cordia spinescens, magnesium lithospermate (1), calcium rosmarinate (2) and magnesium rosmarinate (3) were isolated as potent inhibitory substances against HIV-1 reverse transcriptase (RT) with IC50 values of 0.8, 5.8 and 3.1 μM, respectively. However, they were weak HIV-1 protease (PR) inhibitors with IC50 >100 μM. The RT inhibition by these compounds was noncompetitive with respect to dTTP substrate.
KW - Boraginaceae
KW - Calcium rosmarinate
KW - Cordia spinescens
KW - HIV-1
KW - Magnesium lithospermate
KW - Magnesium rosmarinate
KW - Protease
KW - Reverse transcriptase
UR - http://www.scopus.com/inward/record.url?scp=9844224472&partnerID=8YFLogxK
U2 - 10.1002/(SICI)1099-1573(199711)11:7<490::AID-PTR134>3.0.CO;2-Y
DO - 10.1002/(SICI)1099-1573(199711)11:7<490::AID-PTR134>3.0.CO;2-Y
M3 - 学術論文
AN - SCOPUS:9844224472
SN - 0951-418X
VL - 11
SP - 490
EP - 495
JO - Phytotherapy Research
JF - Phytotherapy Research
IS - 7
ER -
