Inhibition of histone deacetylases protects septic mice from lung and splenic apoptosis

Keyphrases

• Apoptosis 100%
• Lung 100%
• Sepsis 100%
• Histone Deacetylases 100%
• Cecal Puncture 80%
• Cecal Ligation 80%
• CG200745 80%
• Histone Deacetylase Inhibitor (HDACi) 60%
• Histone Acetylation 60%
• Cell Apoptosis 40%
• Anti-apoptotic 40%
• Histone Deacetylase 1 (HDAC1) 40%
• Valproic Acid 40%
• Before Surgery 20%
• Pathophysiology 20%
• Inflammation 20%
• Spleen 20%
• Apoptosis Induction 20%
• Protein Level 20%
• Intraperitoneal Injection 20%
• Anti-inflammatory Effect 20%
• Balb C Mice 20%
• Pro-apoptotic 20%
• Histone Deacetylase 2 (HDAC2) 20%
• Histone Deacetylase 3 (HDAC3) 20%
• Lung Inflammation 20%
• Anti-apoptosis 20%
• Serum Cytokines 20%
• Polymicrobial Sepsis 20%
• Inflammatory Features 20%
• Bcl-2 Family 20%
• Class I HDACs 20%
• Septic Infection 20%
• Epigenetic Programming 20%
• Histone H4 Acetylation 20%

Pharmacology, Toxicology and Pharmaceutical Science

• Sepsis 100%
• Histone Deacetylase 100%
• Antiapoptotic 75%
• Histone Deacetylase Inhibitor 75%
• Inflammation 50%
• Cecal Ligation and Puncture-Induced Sepsis 50%
• Histone 50%
• Sodium Valproate 50%
• Cytokine 25%
• Intraperitoneal Injection 25%
• Antiinflammatory Activity 25%
• Bagg Albino Mouse 25%
• Histone H3 25%
• Pneumonia 25%
• Pathophysiology 25%
• Histone H4 25%
• Histone Deacetylase 1 25%
• Histone Deacetylase 2 25%
• Histone Deacetylase 3 25%

Immunology and Microbiology

• Histone Acetylation 100%
• Upregulation 50%
• Cytokine 50%
• Antiinflammatory Activity 50%
• Downregulation 50%
• Bcl-2 50%
• Bagg Albino Mouse 50%
• Acetylation 50%
• Pulmonary Inflammation 50%