TY - JOUR
T1 - Increased pituitary volume in patients with established bipolar affective disorder
AU - Takahashi, Tsutomu
AU - Malhi, Gin S.
AU - Wood, Stephen J.
AU - Walterfang, Mark
AU - Yücel, Murat
AU - Lorenzetti, Valentina
AU - Soulsby, Bridget
AU - Suzuki, Michio
AU - Velakoulis, Dennis
AU - Pantelis, Christos
N1 - Funding Information:
Neuroimaging analysis was facilitated by the Neuropsychiatry Imaging Laboratory at the Melbourne Neuropsychiatry Centre and supported by Neurosciences Victoria. This study was supported in part by a Grants-in-Aid for Scientific Research (No. 19591346) from the Japanese Society for the Promotion of Science, and a Research Grant (17-2,18-6) for Nervous and Mental Disorders from the Ministry of Health and Welfare, Japan. A/Prof. Wood is currently supported by an NHMRC Clinical Career Developmental Award and a NARSAD Young Investigator Award. Dr. Walterfang was supported by a Pfizer Neuroscience Research Grant. A/Prof. Yücel is supported by NHMRC Clinical Career Development Grant 509345. Prof. Malhi is supported by an NHMRC Program Grant 510135.
PY - 2009/10/1
Y1 - 2009/10/1
N2 - Hypothalamic-pituitary-adrenal (HPA) axis dysfunction has been demonstrated in bipolar disorder (BD), but previous magnetic resonance imaging (MRI) studies of pituitary gland volume in BD have reported variable findings. In this MRI study we investigated pituitary volume in 26 patients with established bipolar I disorder (8 males and 18 females, mean age = 38.4 years) and 24 matched controls (7 males and 17 females, mean age = 38.7 years). The BD patients had a significantly larger pituitary volume as compared with controls, but there was no association between pituitary volume and illness duration, number of manic/depressive episodes, daily medication dosage, family history, or clinical subtype (i.e., psychotic and nonpsychotic). Pituitary volume was larger in females than in males for both groups. These results support previous neuroendocrine findings that implicate HPA axis dysfunction in the core pathophysiological process of BD.
AB - Hypothalamic-pituitary-adrenal (HPA) axis dysfunction has been demonstrated in bipolar disorder (BD), but previous magnetic resonance imaging (MRI) studies of pituitary gland volume in BD have reported variable findings. In this MRI study we investigated pituitary volume in 26 patients with established bipolar I disorder (8 males and 18 females, mean age = 38.4 years) and 24 matched controls (7 males and 17 females, mean age = 38.7 years). The BD patients had a significantly larger pituitary volume as compared with controls, but there was no association between pituitary volume and illness duration, number of manic/depressive episodes, daily medication dosage, family history, or clinical subtype (i.e., psychotic and nonpsychotic). Pituitary volume was larger in females than in males for both groups. These results support previous neuroendocrine findings that implicate HPA axis dysfunction in the core pathophysiological process of BD.
KW - Bipolar disorder
KW - Hypothalamic-pituitary-adrenal axis
KW - Magnetic resonance imaging
KW - Pituitary gland
UR - http://www.scopus.com/inward/record.url?scp=69349083465&partnerID=8YFLogxK
U2 - 10.1016/j.pnpbp.2009.07.012
DO - 10.1016/j.pnpbp.2009.07.012
M3 - 学術論文
C2 - 19622379
AN - SCOPUS:69349083465
SN - 0278-5846
VL - 33
SP - 1245
EP - 1249
JO - Progress in Neuro-Psychopharmacology and Biological Psychiatry
JF - Progress in Neuro-Psychopharmacology and Biological Psychiatry
IS - 7
ER -