Incidence and risk factors of intraocular inflammation after brolucizumab treatment in Japan: A Multicenter Age-Related Macular Degeneration Study

Satoru Inoda, Hidenori Takahashi, Maiko Maruyama-Inoue, Shoko Ikeda, Tetsuju Sekiryu, Kanako Itagaki, Hidetaka Matsumoto, Ryo Mukai, Yoshimi Nagai, Masayuki Ohnaka, Sentaro Kusuhara, Akiko Miki, Annabelle A. Okada, Makiko Nakayama, Koji M. Nishiguchi, Jun Takeuchi, Ryusaburo Mori, Koji Tanaka, Shigeru Honda, Takeya KohnoHideki Koizumi, Yasunori Miyara, Yuji Inoue, Hiroki Takana, Tomohiro Iida, Ichiro Maruko, Atsushi Hayashi, Tomoko Ueda-Consolvo, Yasuo Yanagi*

*この論文の責任著者

研究成果: ジャーナルへの寄稿学術論文査読

12 被引用数 (Scopus)

抄録

Purpose:To investigate the incidence of intraocular inflammation (IOI) and its risk factors following intravitreal injections of brolucizumab for neovascular age-related macular degeneration in Japan.Methods:A total of 1,351 Japanese consecutive patients with neovascular age-related macular degeneration who were treated with brolucizumab from May 2020 to May 2022 at 14 institutions were examined. The variables analyzed were the number of brolucizumab injections, time to onset of IOI, and risk factors.Results:Intraocular inflammation developed in 152 eyes (11.3%). Retinal vasculitis and/or retinal occlusion occurred in 53 eyes (3.9%). Ninety-four patients received bilaterally, bilateral IOI occurred in five patients (5.3%). Sixteen eyes (1.2%) had irreversible visual acuity loss and nine eyes (0.67%) had visual loss of three lines or more due to retinal vasculitis and/or retinal occlusion. The cumulative IOI incidence was 4.5%, 10.3%, and 12.2% at 30, 180, and 365 days (1-year), respectively. History of IOI (including retinal vasculitis) and/or retinal occlusion (odds ratio [OR], 5.41; P = 0.0075) and female sex (OR, 1.99; P = 0.0004) were significantly associated with IOI onset.Conclusion:The 1-year cumulative incidence of IOI in Japanese neovascular age-related macular degeneration patients treated with brolucizumab was 12.2%. History of IOI (including retinal vasculitis) and/or retinal occlusion and female sex were significant risk factors.

本文言語英語
ページ(範囲)714-722
ページ数9
ジャーナルRetina
44
4
DOI
出版ステータス出版済み - 2024/04/01

ASJC Scopus 主題領域

  • 眼科学

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