In vivo anti-influenza virus activity of an immunomodulatory acidic polysaccharide isolated from Cordyceps militaris grown on germinated soybeans

Yuko Ohta, Jung Bum Lee, Kyoko Hayashi, Akio Fujita, Ki Park Dong, Toshimitsu Hayashi*

*この論文の責任著者

研究成果: ジャーナルへの寄稿学術論文査読

167 被引用数 (Scopus)

抄録

An acidic polysaccharide (APS) was isolated from the extract of Cordyceps militaris grown on germinated soybeans. Analyses of sugar composition indicated that APS consisted of D-galactose, L-arabinose, D-xylose, L-rhamnose, and D-galacturonic acid. On the basis of the result of methylation analysis, APS was considered to be mainly composed of Araf-(1→, →5)-Araf-(1→, →4)-Galp-(1→ and →4)-GalAp-(1→ residues. When the polysaccharide was intranasally administered, it decreased virus titers in the bronchoalveolar lavage fluid and the lung of mice infected with influenza A virus and increased survival rate. Furthermore, APS increased TNF-α and IFN-γ levels in mice when compared with those of untreated mice. APS enhanced nitric oxide (NO) production and induced iNOS mRNA and protein expressions in RAW 264.7 murine macrophage cells. The induction of mRNA expression of cytokines including IL-1β, IL-6, IL-10, and TNF-α was also observed. These results demonstrated that APS might have beneficial therapeutic effects on influenza A virus infection at least in part by modulation of the immune function of macrophages.

本文言語英語
ページ(範囲)10194-10199
ページ数6
ジャーナルJournal of Agricultural and Food Chemistry
55
25
DOI
出版ステータス出版済み - 2007/12/12

ASJC Scopus 主題領域

  • 化学一般
  • 農業および生物科学一般

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